Browsing BIO Faculty Scholarship by Author "Yang, Shang-You"
Now showing items 1-20 of 51
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Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis
Ning, Bin; Wei, Jianlu; Zhang, Aijun; Gong, Weiming; Fu, Jinqiu; Jia, Tanghong; Yang, Shang-You (Public Library Science, 2015-06-24)Dendritic cells (DCs) play important roles in initiation of the pathogenic processes of autoimmune disorders, such as rheumatoid arthritis (RA). Tolerogenic dendritic cells (tolDCs) are generated from naive DCs and induce ... -
Biocompatibility of Poly-ε-caprolactone-hydroxyapatite composite on mouse bone marrow-derived osteoblasts and endothelial cells
Yu, Haiying; Wooley, Paul H.; Yang, Shang-You (BioMed Central, 2009-02-26)Background. Tissue-engineered bone may be developed by seeding the cells capable of both osteogenesis and vascularization on biocompatible composite scaffolds. The current study investigated the performance of mice bone ... -
Biological characteristics of adult degenerative nucleus pulposus cells in a three-dimensional microcarrier stirring culture system
Ning, Bin; Liu, Haifei; Gong, Weiming; Jiang, Jianhao; Hu, Yougu; Yang, Shang-You (Wiley-Blackwell, 2013-06)A major problem in reconstructing degenerative intervertebral discs is to obtain sufficient nucleus pulposus (NP) seeding cells with normal physiologic functions. The current study adopted a three-dimensional microcarrier ... -
Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy
Yang, Shuye; Zhang, Kai; Li, Fangfang; Jiang, Jianhao; Jia, Tanghong; Yang, Shang-You (John Wiley & Sons, Inc., 2015-11)This study compared the particulate and ion forms of a cobalt-chrome (Co-Cr) alloy on the differentiation/activation of preosteoblasts. Mouse preosteoblasts (MC3T3-E1) were cultured in an osteoblast-induction medium in the ... -
Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model
Zhang, L.; Jia, Tanghong; Chong, A.C.; Bai, Ling; Yu, Haiying; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Nature Publishing Group, 2010-10)Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee ... -
Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation
Zhang, Kai; Jia, Tanghong; McQueen, David A.; Gong, Weiming; Markel, David C.; Wooley, Paul H.; Yang, Shang-You (Springer-Verlag, 2009-12)Objective To examine the trafficking of human circulating blood monocytes and their influence on the inflammation of periprosthetic tissues using a novel mouse–human chimera model. Methods Periprosthetic tissue ... -
Cobalt-chromium particles inducing preosteoblasts may aggravate periprosthetic inflammation
Jiang, Jianhao; Li, Peng; Du, Gangqiang; Liu, Hongzhi; Wang, Hui; Zhang, Kai; Yang, Shang-You; Yang, Shuye (Journal of Clinical Rehabilitative Tissue Engineering Research, 2019)BACKGROUND: Arthroplasty has been the most effective treatment for the end-stage osteoarthritis. However, aseptic loosening is the main long-term complication of arthroplasty. How to ameliorate aseptic loosening is an issue ... -
Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic loosening
Wang, H.; Jia, Tanghong; Zacharias, Nora M.; Gong, Weiming; Du, Hongxia; Wooley, Paul H.; Yang, Shang-You (Macmillan Publishers Limited, 2013-02)This study investigated the efficacy of a combination gene therapy to repress interleukin-1 (IL-1) and receptor activator of nuclear factor NF-kappa B ligand (RANKL) for the treatment of particulate debris-induced aseptic ... -
Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris
Jiang, Yunpeng; Jia, Tanghong; Wooley, Paul H.; Yang, Shang-You (Acta Orthopaedica Belgica, 2013-02)Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually ... -
DEPDC1 as a crucial factor in the progression of human osteosarcoma
Shen, Lin; Li, Han; Liu, Ronghan; Zhou, Chendan; Bretches, Morgan; Gong, Xuan; Lu, Laitong; Zhang, Ying; Zhao, Kai; Ning, Bin; Yang, Shang-You; Zhang, Aijun (John Wiley & Sons, Ltd, 2022-12-07)Objective: Novel therapeutic strategies are emerging with the increased understanding of the underlying mechanisms of human osteosarcoma. This current study tends to decipher the potentially critical role of DEP domain-containing ... -
Different influence of Ti, PMMA, UHMWPE, and Co-Cr particles on peripheral blood monocytes during periprosthetic inflammation
Zhang, Kai; Yang, Shang-You; Yang, Shuye; Bai, Ling; Li, Peng; Liu, Dong; Schurman, John R.; Wooley, Paul H. (Wiley Periodicals, Inc., 2015-01)This study investigated cellular trafficking and inflammatory markers in orthopedic biomaterial particle-challenged human peripheral blood monocytes (PBMCs) using a murine immunodeficiency (SCID) model. Periprosthetic ... -
Differentiation of nerve-derived adult pluripotent stem cells into osteoblastic and endothelial cells
Yang, Shang-You; Strong, Nora M.; Gong, Xuan; Heggeness, Michael H. (Elsevier B.V., 2017-02)BACKGROUND CONTEXT: Stem cell-involved tissue engineering has gained dramatic attention as a therapeutic strategy for tissue regeneration including bone repair. However, the currently available possibilities to use embryonic ... -
Distinct gene expression of receptor activator of nuclear factor-kappaB and rank ligand in the inflammatory response to variant morphologies of UHMWPE particles
Ren, Weiping; Yang, Shang-You; Fang, Hsu-Wei; Hsu, Stephen; Wooley, Paul H. (Elsevier, 2003-11)Recent studies have examined the role of wear debris-induced bone resorption in the aseptic loosening of orthopedic prostheses. Research has shown that inflammation depends not only on the amount of particulate debris, but ... -
DR5 and DcR2 are expressed in human lumbar intervertebral discs
Chen, Bohua; Ma, Bin; Yang, Shang-You; Xing, Xiuhua; Gu, Run; Hu, Yougu (Lippincott, Williams & Wilkins, 2009-09-01)STUDY DESIGN: To conform the 3 media way of the apoptosis for the degenerative lumbar disc with DR5 (TRAIL-R2) and DcR2 (TRAIL-R4), as one of the tumor necrosis factors family. OBJECTIVE: To detect the expression of the ... -
Effect of BMP-2 adherent to resorbable sutures on cartilage repair: A rat model of xyphoid process
Drummond, Nathan; Bruner, Bradley W.; Heggeness, Michael H.; Dart, Bradley; Yang, Shang-You (MDPI AG, 2020-08-26)Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects ... -
The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure
Zhang, Tao; Yu, Haiying; Gong, Weiming; Zhang, Laibo; Jia, Tanghong; Wooley, Paul H.; Yang, Shang-You (Elsevier, 2009-10)Using an in vivo adeno-associated virus (AAV)-mediated gene transfer technique, this study evaluated the therapeutic effects of an osteoprotegerin (OPG) transgene against orthopaedic wear debris-induced osteolysis in a ... -
Effect of porosity and pore size on microstructures and mechanical properties of poly-epsilon-caprolactone- hydroxyapatite composites
Yu, Haiying; Matthew, Howard W.; Wooley, Paul H.; Yang, Shang-You (Wiley Periodicals, Inc., 2008-03)The influence of variant pore-size and porosity on the microstructure and the mechanical properties of poly-ε-caprolactone (PCL) and hydroxyapatite (HA) composite were examined for an optimal scaffold in bone tissue ... -
Effect of Scutellarin inhibits collagen-induced arthritis through TLR4/NF-kappa B-mediated inflammation
Zhang, Laibo; Sun, Shui; Li, Wei; Zhang, Wei; Wang, Xianquan; Yang, Shang-You (D.A. Spandidos, 2017-10)Scutellarin is the major effective constituent of the commonly used Chinese medicine Erigeron breviscapus. It has been applied in the clinic to treat various diseases, and is characterized by high content, a stable source, ... -
The effects of epidural application of allografted nucleus pulposus in rats on cytokine expression, limb withdrawal and nerve root discharge
Kallakuri, Srinivasu; Takebayashi, Tsuneo; Ozaktay, A. Cuneyt; Chen, Chaoyang; Yang, Shang-You; Wooley, Paul H.; Cavanaugh, John M. (Springer-Verlag, 2005-12-14)This study investigated cytokine expression, behavioral and neurophysiologic changes in Lewis rats whose lumbar nerve roots were exposed to nucleus pulposus (NP). Allografted NP or fat was implanted over the left L5 nerve ... -
Effects of hypoxia on proliferation and apoptosis of osteosarcoma cells
Yang, Shang-You; Garcia, Elka S.; Xia, Will; Wang, Anyu (International Institute of Anticancer Research, 2021-09-30)Background: Hypoxia can happen during solid tumor growth including osteosarcoma. This study investigated the relationship of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) on osteosarcoma ...