Browsing BIO Faculty Scholarship by Author "Webster, Keith A."

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The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation

Taylor, Alan; Webster, Keith A.; Gustafson, Thomas A.; Kedes, Larry (Springer New York, 1997-04)

The anticancer drug, distamycin A, alters DNA conformation by binding to A/T-rich domains. We propose that binding of the drug to DNA alters transcription factor interactions and that this may alter genetic regulation. We ...