Browsing BIO Faculty Scholarship by Author "Wang, Huizhen"

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Evaluation of in vivo bioactivities of recombinant hypo- (FSH21/18) and fully- (FSH24) glycosylated human FSH glycoforms in Fshb null mice

Wang, Huizhen; May, Jacob; Butnev, Viktor Y.; Shuai, Bin; May, Jeffrey V.; Bousfield, George R.; Kumar, T. Rajendra (Elsevier, Ireland LTD, 2016-12-05)

The hormone - specific FSH beta subunit of the human FSH heterodimer consists of N-linked glycans at Asn(7) and Asn(24) residues that are co-translationally attached early during subunit biosynthesis. Differences in the ...
A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7 Delta) Asn(24 Delta)) FSH beta subunit fails to rescue Fshb null mice

Wang, Huizhen; Butnev, Vladimir Y.; Bousfield, George R.; Kumar, T. Rajendra (Elsevier B.V., 2016-05-05)

Follicle-stimulating hormone (FSH) is a gonadotrope-derived heterodimeric glycoprotein. Both the common alpha and hormone-specific beta subunits contain Asn-linked N-glycan chains. Recently, macro heterogeneous FSH glycoforms ...