Browsing BIO Faculty Scholarship by Author "Taylor, Alan"
Now showing items 1-4 of 4
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Alternative method for isolation of double-stranded template for DNA sequencing
Sadiev, Sagypash; Taylor, Alan (Informa Healthcare, 1996-08)The increased use of plasmid DNAs in recombinant DNA technology, coupled with the growing popularity of double-stranded DNA sequencing, necessitates the development of rapid, inexpensive and efficient procedures ... -
The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation
Taylor, Alan; Webster, Keith A.; Gustafson, Thomas A.; Kedes, Larry (Springer New York, 1997-04)The anticancer drug, distamycin A, alters DNA conformation by binding to A/T-rich domains. We propose that binding of the drug to DNA alters transcription factor interactions and that this may alter genetic regulation. We ... -
Cell-cycle-specific transcription termination within the human histone H3.3 gene is correlated with specific protein-DNA interactions
Taylor, Alan; Zhang, L.; Herrmann, J; Wu, Bei; Kedes, Larry; Wells, D. (Cambridge University Press, 1997-04)In vitro studies using highly purified calf thymus RNA polymerase II and a fragment spanning the first intron of H3.3 as template DNA have demonstrated the existence of a strong transcription termination site consisting ... -
DNA sequence and muscle-specific expression of human sarcosin transcripts
Taylor, Alan; Obholz, Kevin; Linden, Gabriele; Sadiev, Sagypash; Klaus, Shelly; Carlson, Kecia D. (Springer New York, 1998-06)We have characterized two abundant human cDNAs which, through Northern hybridization analysis, are selectively expressed in human sarcomeric muscle. DNA sequencing was performed and the two cDNAs were found to share sequence ...