Browsing BIO Faculty Scholarship by Author "Kedes, Larry"

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The anti-cancer agent distamycin A displaces essential transcription factors and selectively inhibits myogenic differentiation

Taylor, Alan; Webster, Keith A.; Gustafson, Thomas A.; Kedes, Larry (Springer New York, 1997-04)

The anticancer drug, distamycin A, alters DNA conformation by binding to A/T-rich domains. We propose that binding of the drug to DNA alters transcription factor interactions and that this may alter genetic regulation. We ...
Cell-cycle-specific transcription termination within the human histone H3.3 gene is correlated with specific protein-DNA interactions

Taylor, Alan; Zhang, L.; Herrmann, J; Wu, Bei; Kedes, Larry; Wells, D. (Cambridge University Press, 1997-04)

In vitro studies using highly purified calf thymus RNA polymerase II and a fragment spanning the first intron of H3.3 as template DNA have demonstrated the existence of a strong transcription termination site consisting ...