Browsing BIO Faculty Scholarship by Author "Johnson, Gillian P."

Now showing items 1-2 of 2

Follicle-stimulating hormone glycosylation variants distinctly modulate pre-antral follicle growth and survival

Johnson, Gillian P.; Onabanjo, Caitlan G. A.; Hardy, Kate; Butnev, Viktor Y.; Bousfield, George R.; Jonas, Kim C. (NLM (Medline), 2022-10-06)

Follicle-stimulating hormone (FSH) is a key endocrine regulator of ovarian function. FSH is secreted as 2 macroglycosylation variants: partially glycosylated FSH (FSH21/18) and fully glycosylated FSH (FSH24). FSH21/18 is ...
Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: Enhanced transcription and PI3K and MAPK signaling

Hua, Guohua; George, Jitu W.; Clark, Kendra L.; Jonas, Kim C.; Johnson, Gillian P.; Southekal, Siddesh; Guda, Chittibabu; Hou, Xiaoying; Blum, Haley R.; Eudy, James; Butnev, Viktor Y.; Brown, Alan (Oxford University Press, 2021-06)

STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ...