Browsing BIO Faculty Scholarship by Author "Jiang, Jianhao"
Now showing items 1-7 of 7
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Biological characteristics of adult degenerative nucleus pulposus cells in a three-dimensional microcarrier stirring culture system
Ning, Bin; Liu, Haifei; Gong, Weiming; Jiang, Jianhao; Hu, Yougu; Yang, Shang-You (Wiley-Blackwell, 2013-06)A major problem in reconstructing degenerative intervertebral discs is to obtain sufficient nucleus pulposus (NP) seeding cells with normal physiologic functions. The current study adopted a three-dimensional microcarrier ... -
Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy
Yang, Shuye; Zhang, Kai; Li, Fangfang; Jiang, Jianhao; Jia, Tanghong; Yang, Shang-You (John Wiley & Sons, Inc., 2015-11)This study compared the particulate and ion forms of a cobalt-chrome (Co-Cr) alloy on the differentiation/activation of preosteoblasts. Mouse preosteoblasts (MC3T3-E1) were cultured in an osteoblast-induction medium in the ... -
Cobalt-chromium particles inducing preosteoblasts may aggravate periprosthetic inflammation
Jiang, Jianhao; Li, Peng; Du, Gangqiang; Liu, Hongzhi; Wang, Hui; Zhang, Kai; Yang, Shang-You; Yang, Shuye (Journal of Clinical Rehabilitative Tissue Engineering Research, 2019)BACKGROUND: Arthroplasty has been the most effective treatment for the end-stage osteoarthritis. However, aseptic loosening is the main long-term complication of arthroplasty. How to ameliorate aseptic loosening is an issue ... -
Gene delivery with PCL nanofiber in vitro
Ceylan, Muhammet; Jiang, Jianhao (Wichita State University. Graduate School, 2013-05-08)Gene therapy has widely been known to be the promising treatment approach for many diseases, whether acquired or inherited through a genetic disorder. Viral and nonviral vectors are the primary research fields of gene ... -
Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma
Gong, Xuan; Jiang, Jianhao; Ceylan, Muhammet; Dart, Bradley; Asmatulu, Ramazan; Yang, Shang-You (Society for Biomaterials, 2019-05)The first line of treatment regime for bone cancers including osteosarcoma is surgical removal of the primary tumor, scaffold and/or bone fillers are required to fill the bone void during the surgery. Development and ... -
Macrophage polarization in IL-10 treatment of particle-induced inflammation and osteolysis
Jiang, Jianhao; Jia, Tanghong; Gong, Weiming; Ning, Bin; Wooley, Paul H.; Yang, Shang-You (Elsevier B.V., 2016-01)This study investigated the therapeutic influence and potential mechanism of IL-10 in ameliorating orthopedic debris particle-induced inflammation and osteolysis. A murine air pouch with bone implantation and polyethylene ... -
Particulate and ion forms of cobalt–chromium challenged preosteoblasts promote osteoclastogenesis and osteolysis in a murine model of prosthesis failure
Yang, Shuye; Zhang, Kai; Jiang, Jianhao; James, Bonface; Yang, Shang-You (Wiley, 2018-10-25)This study investigated the interactive behavior of the particulate and ion forms of cobalt–chromium (Co–Cr) alloy challenged preosteoblasts during the process of prosthetic implant loosening. Preosteoblasts were challenged ...