Browsing BIO Faculty Scholarship by Author "Jiang, Chao"

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Hypo-glycosylated hFSH binds and activates FSH receptors more rapidly than fully-glycosylated hFSH

Bousfield, George R.; Butnev, Vladimir Y.; May, Jeffrey V.; Harvey, David J.; Jiang, Chao; Davis, John S. (FASEB: Federation of American Societies for Experimental Biology, 2013-04)

Follitropin (FSH) heterodimers possess two potential N-glycosylation sites on both common α and hormone-specific β subunits. Hypo-glycosylated hFSH isolated from lutropin preparations possessed a partially glycosylated ...
Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells

Jiang, Chao; Hou, Xiaoying; Wang, Cheng; May, Jeffrey V.; Butnev, Viktor Y.; Bousfield, George R.; Davis, John S. (Endocrine Society, 2015-06)

Context: Previous studies suggest that aging in women is associated with a reduction in hypoglycosylated forms of FSH. Objective: Experiments were performed to determine whether glycosylation of the FSH beta subunit modulates ...