Browsing BIO Faculty Scholarship by Author "Jia, Tanghong"
Now showing items 1-13 of 13
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Antigen-specific tolerogenic dendritic cells ameliorate the severity of murine collagen-induced arthritis
Ning, Bin; Wei, Jianlu; Zhang, Aijun; Gong, Weiming; Fu, Jinqiu; Jia, Tanghong; Yang, Shang-You (Public Library Science, 2015-06-24)Dendritic cells (DCs) play important roles in initiation of the pathogenic processes of autoimmune disorders, such as rheumatoid arthritis (RA). Tolerogenic dendritic cells (tolDCs) are generated from naive DCs and induce ... -
Biological responses of preosteoblasts to particulate and ion forms of Co-Cr alloy
Yang, Shuye; Zhang, Kai; Li, Fangfang; Jiang, Jianhao; Jia, Tanghong; Yang, Shang-You (John Wiley & Sons, Inc., 2015-11)This study compared the particulate and ion forms of a cobalt-chrome (Co-Cr) alloy on the differentiation/activation of preosteoblasts. Mouse preosteoblasts (MC3T3-E1) were cultured in an osteoblast-induction medium in the ... -
Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model
Zhang, L.; Jia, Tanghong; Chong, A.C.; Bai, Ling; Yu, Haiying; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Nature Publishing Group, 2010-10)Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee ... -
Circulating blood monocytes traffic to and participate in the periprosthetic tissue inflammation
Zhang, Kai; Jia, Tanghong; McQueen, David A.; Gong, Weiming; Markel, David C.; Wooley, Paul H.; Yang, Shang-You (Springer-Verlag, 2009-12)Objective To examine the trafficking of human circulating blood monocytes and their influence on the inflammation of periprosthetic tissues using a novel mouse–human chimera model. Methods Periprosthetic tissue ... -
Combination gene therapy targeting on interleukin-1β and RANKL for wear debris-induced aseptic loosening
Wang, H.; Jia, Tanghong; Zacharias, Nora M.; Gong, Weiming; Du, Hongxia; Wooley, Paul H.; Yang, Shang-You (Macmillan Publishers Limited, 2013-02)This study investigated the efficacy of a combination gene therapy to repress interleukin-1 (IL-1) and receptor activator of nuclear factor NF-kappa B ligand (RANKL) for the treatment of particulate debris-induced aseptic ... -
Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris
Jiang, Yunpeng; Jia, Tanghong; Wooley, Paul H.; Yang, Shang-You (Acta Orthopaedica Belgica, 2013-02)Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually ... -
The effect of osteoprotegerin gene modification on wear debris-induced osteolysis in a murine model of knee prosthesis failure
Zhang, Tao; Yu, Haiying; Gong, Weiming; Zhang, Laibo; Jia, Tanghong; Wooley, Paul H.; Yang, Shang-You (Elsevier, 2009-10)Using an in vivo adeno-associated virus (AAV)-mediated gene transfer technique, this study evaluated the therapeutic effects of an osteoprotegerin (OPG) transgene against orthopaedic wear debris-induced osteolysis in a ... -
Effects of Ti, PMMA, UHMWPE, and Co-Cr wear particles on differentiation and functions of bone marrow stromal cells
Jiang, Yunpeng; Jia, Tanghong; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (John Wiley and Sons, 2013-10)This study investigates the roles of orthopedic biomaterial particles [Ti-alloy, poly(methyl methacrylate) (PMMA), ultrahigh-molecular-weight polyethylene (UHMWPE), Co-Cr alloy] on the differentiation and functions of bone ... -
Human peripheral nerve-derived pluripotent cells can be stimulated by in vitro bone morphogenetic protein-2
Sun, Renyi; Jia, Tanghong; Dart, Bradley; Shrestha, Sunaina; Bretches, Morgan; Heggeness, Michael H.; Yang, Shang-You (MDPI, 2021-09-26)We have recently identified a population of cells within the peripheral nerves of adult rodent animals (mice and rats) that can respond to Bone Morphogenetic Protein-2 (BMP-2) exposure or physical injury to rapidly ... -
Macrophage polarization in IL-10 treatment of particle-induced inflammation and osteolysis
Jiang, Jianhao; Jia, Tanghong; Gong, Weiming; Ning, Bin; Wooley, Paul H.; Yang, Shang-You (Elsevier B.V., 2016-01)This study investigated the therapeutic influence and potential mechanism of IL-10 in ameliorating orthopedic debris particle-induced inflammation and osteolysis. A murine air pouch with bone implantation and polyethylene ... -
Microcarrier bioreactor culture system promotes propagation of human intervertebral disc cells
Zhang, L.; Ning, Bin; Jia, Tanghong; Gong, Weiming; Cong, M.; Chen, J.F.; Yang, Shang-You (Springer-Verlag, 2010-12)Background Cell-based tissue engineering has emerged as a potential therapy for intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge. Aims To ... -
Titanium Particle-Challenged Osteoblasts Promote Osteoclastogenesis and Osteolysis in a Murine Model of Periprosthestic Osteolysis
Jiang, Yunpeng; Jia, Tanghong; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Elsevier, 2013-03-19)The current study investigates the interactive behavior of titanium alloy particle-challenged osteoblastic bone marrow stromal cells (BMSCs) and macrophage lineage cells in a murine knee-prosthesis failure model. BMSCs ... -
VEGF blockade decelerates the growth of a murine experimental osteosarcoma
Yin, De-zhen; Jia, Tanghong; Gong, Weiming; Yu, Haiying; Wooley, Paul H.; Mott, Michael P. (Spandidos Publications, 2008-08)Retrovirus-mediated sFlt-1 gene modification was performed to examine the influence of VEGF in controlling the growth of an experimental osteosarcoma in mice. Human osteosarcoma G-292 cells were in vitro infected with ...