Browsing BIO Faculty Scholarship by Author "Heggeness, Michael H."
Now showing items 1-5 of 5
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Differentiation of nerve-derived adult pluripotent stem cells into osteoblastic and endothelial cells
Yang, Shang-You; Strong, Nora M.; Gong, Xuan; Heggeness, Michael H. (Elsevier B.V., 2017-02)BACKGROUND CONTEXT: Stem cell-involved tissue engineering has gained dramatic attention as a therapeutic strategy for tissue regeneration including bone repair. However, the currently available possibilities to use embryonic ... -
Effect of BMP-2 adherent to resorbable sutures on cartilage repair: A rat model of xyphoid process
Drummond, Nathan; Bruner, Bradley W.; Heggeness, Michael H.; Dart, Bradley; Yang, Shang-You (MDPI AG, 2020-08-26)Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects ... -
Human peripheral nerve-derived pluripotent cells can be stimulated by in vitro bone morphogenetic protein-2
Sun, Renyi; Jia, Tanghong; Dart, Bradley; Shrestha, Sunaina; Bretches, Morgan; Heggeness, Michael H.; Yang, Shang-You (MDPI, 2021-09-26)We have recently identified a population of cells within the peripheral nerves of adult rodent animals (mice and rats) that can respond to Bone Morphogenetic Protein-2 (BMP-2) exposure or physical injury to rapidly ... -
Quiescent pluripotent stem cells reside within murine peripheral nerves that can be stimulated to proliferate by recombinant human bone morphogenic protein 2 or by nerve trauma
Heggeness, Michael H.; Strong, Nora M.; Wooley, Paul H.; Yang, Shang-You (Elsevier B.V., 2017-02)BACKGROUND: The clinical use of recombinant human bone morphogenic protein 2 (rhBMP2, Infuse) has been associated with nerve-related complications including new-onset sciatica, and retrograde ejaculation. PURPOSE: To ... -
Therapeutic effects of naringin on degenerative human nucleus pulposus cells for discogenic low back pain
Li, Nianhu; Whitaker, Camden; Xu, Zhanwang; Heggeness, Michael H.; Yang, Shang-You (Elsevier B.V., 2016-10)BACKGROUND: Over half the population of the world will suffer from moderate or severe low back pain (LBP) during their life span. Studies have shown that naringin, a major flavonoid in grapefruit and an active compound ...