Now showing items 1-7 of 7

    • Differential effects of alpha subunit Asparagine56 oligosaccharide structure on equine lutropin and follitropin hybrid conformation and receptor-binding activity 

      Bousfield, George R.; Butnev, Vladimir Y.; Butnev, Viktor Y.; Nguyen, Van T.; Gray, Ciann M.; Dias, James A.; MacColl, Robert; Eisele, Leslie; Harvey, David J. (American Chemical Society, 2004-08-24)
      The gonadotropins, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and chorionic gonadotropin (CG), are cysteine-knot growth-factor superfamily glycoproteins composed of a common alpha subunit noncovalently ...
    • Editorial for the MCE special issue on “Novel endocrine mechanisms in the regulation of reproduction” 

      Dias, James A.; Ulloa-Aguirre, Alfredo; Bousfield, George R.; Reiter, Eric (Elsevier B.V., 2014-01-25)
      This volume is intended to serve as a reference for the most current understanding of several reproductive system topics, which cluster around the functioning and development of the systemic physiology of the hypothalami ...
    • Gonadotropins and the importance of glycosylation 

      Ulloa-Aguirre, Alfredo; Dias, James A.; Bousfield, George R. (Wiley-VCH Verlag GmbH & Co. KGaA, 2009-09-25)
      From the leading author in the field, known around the world for his work and his authoritative publications, the contents of this book have been selected so as to reflect their relative importance for biopharmaceuticals. ...
    • In vivo and in vitro impact of carbohydrate variation on human follicle-stimulating hormone function 

      Bousfield, George R.; May, Jeffrey V.; Davis, John S.; Dias, James A.; Kumar, T. Rajendra (Frontiers Media S.A., 2018-05-09)
      Human follicle-stimulating hormone (FSH) exhibits both macro-and microheterogeneity in its carbohydrate moieties. Macroheterogeneity results in three physiologically relevant FSH beta subunit variants, two that possess a ...
    • Inositol phosphate stimulation by LH requires the entire alpha Asn56 oligosaccharide 

      Nguyen, Van T.; Singh, Vinod; Butnev, Vladimir Y.; Gray, Ciann M.; Westfall, Suzanne; Davis, John S.; Dias, James A.; Bousfield, George R. (Elsevier Ireland Ltd, 2003-01-31)
      Lentil lectin-bound, fucose-enriched hTSH was reported to stimulate both cAMP and inositol phosphate (IP) intracellular signalling pathways, whereas fucose-depleted hTSH stimulated only the cAMP pathway. Gonadotropins ...
    • Synthesis and secretion of gonadotropins including structure-function correlates 

      Bousfield, George R.; Dias, James A. (Springer Open Choice, 2011-07-08)
      The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production ...
    • Trafficking of the follitropin receptor 

      Ulloa-Aguirre, Alfredo; Dias, James A.; Bousfield, George R.; Huhtaniemi, Ilpo; Reiter, Eric (Elsevier, 2013)
      The follitropin or follicle-stimulating hormone receptor (FSHR) belongs to a highly conserved subfamily of the G protein-coupled receptor (GPCR) superfamily and is mainly expressed in specific cells in the gonads. As any ...