Browsing BIO Faculty Scholarship by Author "Beier, David R."

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    • Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis 

      Herron, Bruce J.; Lu, Weining; Rao, Cherie; Liu, Shanming; Peters, Heiko; Bronson, Roderick T.; Justice, Monica J.; McDonald, J. David; Beier, David R. (Nature Publishing Group, 2002)
      Treatment with N-ethyl-N-nitrosourea (ENU) efficiently generates single-nucleotide mutations in mice. Along with the renewed interest in this approach, much attention has been given recently to large screens with broad ...

    • ENU mutagenesis in the mouse 

      McDonald, J. David; Beier, David R. (John Wiley & Sons, 2004-02)
      This unit describes the treatment of laboratory mice with the mutagen N-ethyl-N-nitrosourea (ENU) to achieve very highly induced rates of mutation throughout the genome. Further, it describes several popular mating schemes ...