Browsing BIO Faculty Scholarship by Author "Bai, Ling"
Now showing items 1-3 of 3
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Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model
Zhang, L.; Jia, Tanghong; Chong, A.C.; Bai, Ling; Yu, Haiying; Gong, Weiming; Wooley, Paul H.; Yang, Shang-You (Nature Publishing Group, 2010-10)Exogenous OPG gene modification appears a therapeutic strategy for osteolytic aseptic loosening. The feasibility and efficacy of a cell-based OPG gene delivery approach were investigated using a murine model of knee ... -
Different influence of Ti, PMMA, UHMWPE, and Co-Cr particles on peripheral blood monocytes during periprosthetic inflammation
Zhang, Kai; Yang, Shang-You; Yang, Shuye; Bai, Ling; Li, Peng; Liu, Dong; Schurman, John R.; Wooley, Paul H. (Wiley Periodicals, Inc., 2015-01)This study investigated cellular trafficking and inflammatory markers in orthopedic biomaterial particle-challenged human peripheral blood monocytes (PBMCs) using a murine immunodeficiency (SCID) model. Periprosthetic ... -
Polymethylmethacrylate and titanium alloy particles activate peripheral monocytes during periprosthetic inflammation and osteolysis
Yang, Shang-You; Zhang, Kai; Bai, Ling; Song, Zheng; Yu, Haiying; McQueen, David A.; Wooley, Paul H. (Wiley Periodicals, Inc., 2011-05)We investigated the interactions of particulate PMMA or titanium alloy, patient blood monocytes, and periprosthetic tissues using a SCID-hu model of aseptic loosening. Periprosthetic tissues and bone chips obtained at ...