Browsing BIO Faculty Scholarship by Title
Now showing items 211-230 of 406
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Hyaluronic acid viscosupplements from avian and non-mammalian sources exhibit biocompatibility profiles with unique, source-specific, antigenic profiles
(Wiley Periodicals, Inc., 2012-04)The objective of this study was to evaluate and compare the biocompatibility profiles of hyaluronic acid (HA) viscosupplements from avian and non-mammalian sources. Inflammatory and immune reactions were assessed in models of ... -
Hyperphenylalaninemia in the hph-1 mouse mutant
(International Pediatrics Research Foundation, 1988-01)A mutation, resulting in a deficiency of liver GTP-cyclohydrolase activity, has been induced in the laboratory mouse. Mice homozygous for this mutation exhibit hyperphenylalaninemia under the following conditions: 1) early ... -
Hypo-glycosylated hFSH binds and activates FSH receptors more rapidly than fully-glycosylated hFSH
(FASEB: Federation of American Societies for Experimental Biology, 2013-04)Follitropin (FSH) heterodimers possess two potential N-glycosylation sites on both common α and hormone-specific β subunits. Hypo-glycosylated hFSH isolated from lutropin preparations possessed a partially glycosylated ... -
Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: Enhanced transcription and PI3K and MAPK signaling
(Oxford University Press, 2021-06)STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ... -
Hypo-glycosylated human follicle-stimulating hormone (hFSH(21)) exhibits higher endocytic rate for recombinant hFSH Receptor than fully-glycosylated hFSH (hFSH(24))
(Federation of American Societies for Experimental Biology, 2015-04)Follicle-stimulating hormone (FSH) plays an essential role in the regulation of reproduction, as FSH KO female mice are sterile. FSH regulates ovarian granulosa and testicular Sertoli cell function by binding to its cognate ... -
Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24))
(Elsevier Ireland Ltd, 2014-02-15)Hypo-glycosylated hFSH21/18 (possesses FSHβ21 and FSHβ18bands) was isolated from hLH preparations by immunoaffinity chromatography followed by gel filtration. Fully-glycosylated hFSH24 was prepared by combining the ... -
Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells
(Endocrine Society, 2015-06)Context: Previous studies suggest that aging in women is associated with a reduction in hypoglycosylated forms of FSH. Objective: Experiments were performed to determine whether glycosylation of the FSH beta subunit modulates ... -
Identification of twelve O-glycosylation sites in equine chorionic gonadotropin beta and equine luteinizing hormone ss by solid-phase Edman degradation
(Society for the Study of Reproduction, 2001-01)The O-glycosylation sites for equine LHss (eLHss) and eCGss were identified by solid-phase Edman degradation of four glycopeptides derived from the C-terminal region. Both subunits were O-glycosylated at the same 12 ... -
Identifying multiple origins of polyploid taxa: A multilocus study of the hybrid cloak fern (Astrolepis integerrima; Pteridaceae).
(BOTANICAL SOC AMER INC, 2012-11)Premise of the study: Molecular studies have shown that multiple origins of polyploid taxa are the rule rather than the exception. To understand the distribution and ecology of polyploid species and the evolutionary ... -
Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma
(Society for Biomaterials, 2019-05)The first line of treatment regime for bone cancers including osteosarcoma is surgical removal of the primary tumor, scaffold and/or bone fillers are required to fill the bone void during the surgery. Development and ... -
Immunochemical mapping of human lutropin: I. Delineation of a conformational antigenic determinant
(Elsevier Ireland Ltd., 1994-05)Lutropin (LH), follitropin (FSH), thyrotropin (TSH) and choriogonadotropin (CG) are assembled of two non-covalently alpha (α) and beta (β) subunits. We studied the discontinuous antigenic regions recognized by a monoclonal ... -
Immunochemical studies of equine chorionic gonadotropin (eCG), eCG alpha, and eCG beta
(The Endocrine Society, 1993-01-01)The equine (e) placental glycoprotein hormone eCG plays a critical though not completely understood role during the first trimester of gestation in mares. In the present work, we have developed immunoradiometric assays ... -
Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene
(Nature Publishing Group, 2013-12)Functionalized biomaterial scaffolds targeted at improving axonal regeneration by enhancing guided axonal growth provide a promising approach for the repair of spinal cord injury. Collagen neural conduits provide structural ... -
Improved tissue-engineered bone regeneration by endothelial cell mediated vascularization
(Elsevier, 2009-02)Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network ... -
Improving axon growth of transected spinal cord using multichannel collagen conduits carrying NT-3 gene
(NATURE PUBLISHING GROUP, 2012-05-01) -
In Vitro Impact of FSH Glycosylation Variants on FSH Receptor-stimulated Signal Transduction and Functional Selectivity
(Oxford University Press, 2020-05)FSH exists as different glycoforms that differ in glycosylation of the hormone-specific β-subunit. Tetra-glycosylated FSH (FSH24) and hypo-glycosylated FSH (FSH18/21) are the most abundant glycoforms found in humans. ... -
In vivo and in vitro impact of carbohydrate variation on human follicle-stimulating hormone function
(Frontiers Media S.A., 2018-05-09)Human follicle-stimulating hormone (FSH) exhibits both macro-and microheterogeneity in its carbohydrate moieties. Macroheterogeneity results in three physiologically relevant FSH beta subunit variants, two that possess a ... -
Increased production of beta-lactamase under anaerobic conditions in some strains of Escherichia coli
(American Society for Microbiology, 1979-07-25)A simple biological assay to detect beta-lactamase activity exhibited by selected cultures of Escherichia coli was used to test enzyme production in cells incubated aerobically and anaerobically. Anaerobic incubation ... -
Increased toxicity to invertebrates associated with a mixture of atrazine and organophosphate insecticides
(John Wiley & Sons, 2002-07)This study examined the joint toxicity of atrazine and three organophosphate (OP) insecticides (chlorpyrifos, methyl parathion, and diazinon) exposed to Hyalella azteca and Musca domestica. A factorial design was used to ... -
Increased urotensin I and II immunoreactivity in the urophysis of Gillichthys mirabilis transferred to low salinity water
(Academic Press, 1991-09)The function of the fish caudal neurosecretory system is uncertain, but a role in osmoregulation has been suggested by many investigators. Our objective was to determine if acclimation to water of different salinity has ...