Browsing BIO Faculty Scholarship by Title
Now showing items 200-219 of 405
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High soil nitrogen levels and insect herbivory suppress tall thistle (Cirsium altissimum) rosette survival
(2012-08)Background/Question/Methods The effect of herbivores on plant performance is often highly variable and the causes of this variability are poorly explained for many herbivore-host plant interactions. Many of the proposed ... -
High VEGF with rapid growth and early metastasis in a mouse osteosarcoma model
(Hindawi Publishing Corporation, 2007-10-19)A murine model of osteosarcoma was developed to investigate the association between the expression of VEGF and the progression of osteosarcoma. Two human osteosarcoma cell lines with distinct VEGF expressions were introduced ... -
Historical patterns of oak population expansion in the Chautauqua Hills, Kansas
(John Wiley & Sons, Inc., 2014-06-18)AimRates of tree population expansion have increased in many North American landscapes that were mosaics of grasslands, savannas and woodlands historically. Consequences of woodland expansion include reduced economic return ... -
Hormone-specific inhibitory influence of alpha-subunit Asn56 oligosaccharide on in vitro subunit association and follicle-stimulating hormone receptor binding of equine gonadotropins
(Society for the Study of Reproduction, 1998-02-01)Hybrid hormones were created using combinations of equine (e) LH, eFSH, and eCG alpha- and beta-subunit preparations. The efficiency of eFSH beta association was highest with eLH alpha (64-72%) and was lowest with eCG alpha ... -
How has the introduction of new bearing surfaces altered the biological reactions to byproducts of wear and modularity?
(Springer International Publishing AG, 2014-12)Background Biological responses to wear debris were largely elucidated in studies focused on conventional ultrahigh-molecular-weight polyethylene (UHMWPE) and some investigations of polymethymethacrylate cement and orthopaedic ... -
Hph-1: A mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis
(PubMed, 1988-02)Ethylnitrosourea mutagenesis of spermatogonial stem cells and a three-generation breeding scheme were used to screen for recessive mutations that cause defects in phenylalanine metabolism leading to elevated serum levels ... -
Human FSH glycoform α-Subunit asparagine$^{52}$ glycans: Major glycan structural consistency, minor glycan variation in abundance
(Frontiers Media S.A., 2022-10-18)Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans. The two most ... -
A human FSHB transgene encoding the double N-glycosylation mutant (Asn(7 Delta) Asn(24 Delta)) FSH beta subunit fails to rescue Fshb null mice
(Elsevier B.V., 2016-05-05)Follicle-stimulating hormone (FSH) is a gonadotrope-derived heterodimeric glycoprotein. Both the common alpha and hormone-specific beta subunits contain Asn-linked N-glycan chains. Recently, macro heterogeneous FSH glycoforms ... -
Human peripheral nerve-derived pluripotent cells can be stimulated by in vitro bone morphogenetic protein-2
(MDPI, 2021-09-26)We have recently identified a population of cells within the peripheral nerves of adult rodent animals (mice and rats) that can respond to Bone Morphogenetic Protein-2 (BMP-2) exposure or physical injury to rapidly ... -
Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor
(Journal of Bone and Joint Surgery, Inc, 2005-05)Background: Periprosthetic tissue formation and local inflammation that are associated with wear debris contribute to the pathogenesis of aseptic loosening of a prosthesis. This study evaluated a retrovirus-mediated gene ... -
Hyaluronic acid viscosupplements from avian and non-mammalian sources exhibit biocompatibility profiles with unique, source-specific, antigenic profiles
(Wiley Periodicals, Inc., 2012-04)The objective of this study was to evaluate and compare the biocompatibility profiles of hyaluronic acid (HA) viscosupplements from avian and non-mammalian sources. Inflammatory and immune reactions were assessed in models of ... -
Hyperphenylalaninemia in the hph-1 mouse mutant
(International Pediatrics Research Foundation, 1988-01)A mutation, resulting in a deficiency of liver GTP-cyclohydrolase activity, has been induced in the laboratory mouse. Mice homozygous for this mutation exhibit hyperphenylalaninemia under the following conditions: 1) early ... -
Hypo-glycosylated hFSH binds and activates FSH receptors more rapidly than fully-glycosylated hFSH
(FASEB: Federation of American Societies for Experimental Biology, 2013-04)Follitropin (FSH) heterodimers possess two potential N-glycosylation sites on both common α and hormone-specific β subunits. Hypo-glycosylated hFSH isolated from lutropin preparations possessed a partially glycosylated ... -
Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: Enhanced transcription and PI3K and MAPK signaling
(Oxford University Press, 2021-06)STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ... -
Hypo-glycosylated human follicle-stimulating hormone (hFSH(21)) exhibits higher endocytic rate for recombinant hFSH Receptor than fully-glycosylated hFSH (hFSH(24))
(Federation of American Societies for Experimental Biology, 2015-04)Follicle-stimulating hormone (FSH) plays an essential role in the regulation of reproduction, as FSH KO female mice are sterile. FSH regulates ovarian granulosa and testicular Sertoli cell function by binding to its cognate ... -
Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24))
(Elsevier Ireland Ltd, 2014-02-15)Hypo-glycosylated hFSH21/18 (possesses FSHβ21 and FSHβ18bands) was isolated from hLH preparations by immunoaffinity chromatography followed by gel filtration. Fully-glycosylated hFSH24 was prepared by combining the ... -
Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells
(Endocrine Society, 2015-06)Context: Previous studies suggest that aging in women is associated with a reduction in hypoglycosylated forms of FSH. Objective: Experiments were performed to determine whether glycosylation of the FSH beta subunit modulates ... -
Identification of twelve O-glycosylation sites in equine chorionic gonadotropin beta and equine luteinizing hormone ss by solid-phase Edman degradation
(Society for the Study of Reproduction, 2001-01)The O-glycosylation sites for equine LHss (eLHss) and eCGss were identified by solid-phase Edman degradation of four glycopeptides derived from the C-terminal region. Both subunits were O-glycosylated at the same 12 ... -
Identifying multiple origins of polyploid taxa: A multilocus study of the hybrid cloak fern (Astrolepis integerrima; Pteridaceae).
(BOTANICAL SOC AMER INC, 2012-11)Premise of the study: Molecular studies have shown that multiple origins of polyploid taxa are the rule rather than the exception. To understand the distribution and ecology of polyploid species and the evolutionary ... -
Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma
(Society for Biomaterials, 2019-05)The first line of treatment regime for bone cancers including osteosarcoma is surgical removal of the primary tumor, scaffold and/or bone fillers are required to fill the bone void during the surgery. Development and ...