• Human peripheral nerve-derived pluripotent cells can be stimulated by in vitro bone morphogenetic protein-2 

  Sun, Renyi; Jia, Tanghong; Dart, Bradley; Shrestha, Sunaina; Bretches, Morgan; Heggeness, Michael H.; Yang, Shang-You (MDPI, 2021-09-26)

  We have recently identified a population of cells within the peripheral nerves of adult rodent animals (mice and rats) that can respond to Bone Morphogenetic Protein-2 (BMP-2) exposure or physical injury to rapidly ...

• Effects of hypoxia on proliferation and apoptosis of osteosarcoma cells 

  Yang, Shang-You; Garcia, Elka S.; Xia, Will; Wang, Anyu (International Institute of Anticancer Research, 2021-09-30)

  Background: Hypoxia can happen during solid tumor growth including osteosarcoma. This study investigated the relationship of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) on osteosarcoma ...

• Habitat associations of carrion beetles (coleoptera: silphidae) across a full annual cycle 

  Engasser, Emmy L.; Stone, Rachel L.; Jameson, Mary Liz (Oxford University Press, 2021-03-05)

  Necrophagous insects play an important role in decomposition and nutrient recycling of decomposing vertebrates. Ecological studies of carrion-associated beetles enhance forensic investigations by providing information about ...

• Heads or tails? Dung beetle (Coleoptera: Scarabaeidae: Scarabaeinae and Aphodiinae) attraction to carrion 

  Stone, Rachel L.; Engasser, Emmy L.; Jameson, Mary Liz (Entomological Society of America, 2021-03-05)

  Necrophilous insects occupy an ecologically interesting niche because carrion is a highly desirable but ephemeral food source. Dung beetles (Coleoptera: Scarabaeidae: Scarabaeinae and Aphodiinae) within temperate regions ...

• Hypo-glycosylated hFSH drives ovarian follicular development more efficiently than fully-glycosylated hFSH: Enhanced transcription and PI3K and MAPK signaling 

  Hua, Guohua; George, Jitu W.; Clark, Kendra L.; Jonas, Kim; Johnson, Gillian P.; Southekal, Siddesh; Guda, Chittibabu; Hou, Xiaoying; Blum, Haley R.; Eudy, James; Butnev, Viktor Y.; Brown, Alan (Oxford University Press, 2021-06)

  STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ...

• Predation landscapes influence migratory prey ecology and evolution 

  Sabal, Megan C.; Boyce, Mark S.; Charpentier, Corie L.; Furey, Nathan B.; Luhring, Thomas M.; Martin, Hans W.; Melnychuk, Michael C.; Srygley, Robert B.; Wagner, C. M.; Wirsing, Aaron J.; Ydenberg, Ronald C.; Palkovacs, Eric P. (Elsevier, 2021-05-13)

  Migratory prey experience spatially variable predation across their life cycle. They face unique challenges in navigating this predation landscape, which affects their perception of risk, antipredator responses, and resulting ...

• Bioscaffold-based study of glioblastoma cell behavior and drug delivery for tumor therapy 

  Tran, Kimmy; Brice, Ryan; Yao, Li (Elsevier, 2021-07-01)

  Glioblastoma multiforme (GBM) is a severe form of brain cancer with an average five-year survival rate of 6.7%. Current treatment strategies include surgical resection of the tumor area and lining the lesion site with ...

• FGDB: Database of follicle stimulating hormone glycans 

  Shakyawar, Sushil K.; Pandey, Sanjit; Harvey, David J.; Bousfield, George R.; Guda, Chittibabu (Elsevier, 2021)

  Glycomics, the study of the entire complement of sugars of an organism has received significant attention in the recent past due to the advances made in high throughput mass spectrometry technologies. These analytical ...

• Botany is the root and the future of invasion biology 

  Sutherland, Brittany L.; Barrett, Craig F.; Beck, James B.; Latvis, Maribeth; McKain, Michael R.; Sigel, Erin; Kooyers, Nicholas J. (Botanical Society of America, 2021-04-23)

  Botanists have always been at the forefront of invasion biology, from early observations to contemporary hypothesis testing with modern tools. Plants have distinct advantages as experimental systems that have and will allow ...

• Two cytotype niche shifts are of different magnitude in Solidago gigantea 

  Martino, Maria; Semple, John C.; Beck, James B. (Botanical Society of America, 2020-11-04)

  Premise: Polyploidy may serve to contribute to range size if autopolyploid cytotypes are adapted to differing ecological conditions. This study aims to establish the geographic distribution of cytotypes within the giant ...

• Biological response of $Co^{2+}$ to preosteoblasts during aseptic loosening of the prosthesis 

  Jiang, Shengyuan; Li, Dan; Jiang, Jianha; Shang-You, Yang; Yang, Shuye (Journal of Clinical Rehabilitative Tissue Engineering Research, 2020-12-31)

  BACKGROUND: Aseptic loosening of prosthesis is the main long-term complication after artificial joint replacement. Metal ions have been proven to be one of the causes of aseptic loosening. How to control and mitigate aseptic ...

• Genetic analysis of the molecular regulation of electric fields-guided glia migration 

  Yao, Li; Shippy, Teresa D.; Li, Yongchao (Nature Research, 2020-10-08)

  In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the ...

• Effect of BMP-2 adherent to resorbable sutures on cartilage repair: A rat model of xyphoid process 

  Drummond, Nathan; Bruner, Bradley W.; Heggeness, Michael H.; Dart, Bradley; Yang, Shang-You (MDPI AG, 2020-08-26)

  Meniscal tears are often seen in orthopedic practice. The current strategy for meniscal repair has only had limited success with a relatively high incidence of re-operative rate. This study evaluates the therapeutic effects ...

• Fabrication and biological analysis of highly porous PEEK bionanocomposites incorporated with carbon and hydroxyapatite nanoparticles for biological applications 

  Swaminathan, Palanivel; Uddin, Md Nizam; Wooley, Paul H.; Asmatulu, Ramazan (NLM (Medline), 2020-08-06)

  Bone regeneration for replacing and repairing damaged and defective bones in the human body has attracted much attention over the last decade. In this research, highly porous polyetheretherketone (PEEK)/hydroxyapatite (HA) ...

• Plant community recovery following Sericea lespedeza (Lespedeza cuneata) removal: testing for a soil legacy effect 

  Reichenborn, Molly M.; Houseman, Gregory R.; Foster, Bryan L. (Blackwell, 2020-04-22)

  Restoration of plant communities can be hindered by the legacy of previously established invaders, despite their physical removal from the community. Current evidence, mainly built on short-term greenhouse experiments, ...

• Exogenous siRNAs against chitin synthase gene suppress the growth of the pathogenic fungus Macrophomina phaseolina 

  Forster, Heather; Shuai, Bin (Taylor and Francis, 2020-04-06)

  Macrophomina phaseolina:, causative agent of the charcoal rot disease, impacts over 500 plant species, causing devastating crop failures worldwide. Due to the lack of effective management approach, charcoal rot can result ...

• Bioactivity of recombinant hFSH glycosylation variants in primary cultures of porcine granulosa cells 

  Liang, Aixin; Plewes, Michele R.; Hua, Guohua; Hou, Xiaoying; Blum, Haley R.; Przygrodzka, Emilia; George, Jitu W.; Clark, Kendra L.; Bousfield, George R.; Butnev, Viktor Y.; May, Jeffrey V.; Davis, John S. (Elsevier, 2020-06-15)

  Previous studies have reported hypo-glycosylated FSH and fully-glycosylated FSH to be naturally occurring in humans, and these glycoforms exist in changing ratios over a woman's lifespan. The precise cellular and molecular ...

• Mars Extant Life: What's Next? Conference Report 

  Schneegurt, Mark A. (Mary Ann Liebert, Inc, 2020-06-10)

  On November 5-8, 2019, the "Mars Extant Life: What's Next?" conference was convened in Carlsbad, New Mexico. The conference gathered a community of actively publishing experts in disciplines related to habitability and ...

• Effects of nitrogen and phosphorus limitation on lipid accumulation by Chlorella kessleri str. UTEX 263 grown in darkness 

  Shrestha, Nayan; Dandinpet, Kiran K.; Schneegurt, Mark A. (Springer, 2020-06-08)

  Growing algae in darkness for biodiesel production eliminates the challenges of evaporation and light penetration reported for open ponds and the costs and fouling that plague photobioreactors. The current study demonstrated ...

• Preparation of bioscaffolds delivering stem cells for neural regeneration 

  Yao, Li; DeBrot, Ashley (Humana, New York, NY, 2020-05-31)

  Bioscaffolds have been proven for their feasibility in neural repair. Neural conduits have been investigated in the repair of wounded peripheral nerve and spinal cord. These conduits support axonal growth by providing ...

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