Improving personalized medicine by examining structure-function patterns in the non-conserved regions of lactate dehydrogenase (LDH)
Alao, Esther Dami
Beck, Moriah R.
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Esther Dami Alao, Allan Ayella, and Moriah Rene Beck Improving Personalized Medicine by Examining Structure-Function Patterns in the Non-Conserved Regions of Lactate Dehydrogenase (LDH) FASEB J April 2017 31:922.5
Personalized medicine relies on our ability to make predictions about disease susceptibility based on differences in protein or gene sequences. Recent research has suggested that the non-conserved regions of proteins, those regions with the greatest variation across species, may act as rheostats in protein function by adjusting protein function gradually. Whereas the conserved regions, or those with high degree of sequence similarity, typically involve the active sites or are regions that have a critical function.
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