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dc.contributorKansas State University Research Foundation
dc.contributorWichita State University
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorKim, Yunjeong
dc.contributor.authorGroutas, William C.
dc.date.accessioned2016-11-08T02:08:48Z
dc.date.available2016-11-08T02:08:48Z
dc.date.issued2016-04-12
dc.date.submitted2013-05-02
dc.identifierUS 9,309,284 B2
dc.identifier.citationKyeong-Ok Chang, Yunjeong Kim, and William C. Groutas, inventors. Kansas State University Research Foundation and Wichita State University, assignees. Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses. United States patent: US 9,309,284. 2016, Apr 12.
dc.identifier.urihttps://patentimages.storage.googleapis.com/c6/71/bf/76206160b4dadc/US9309284.pdf
dc.identifier.urihttp://hdl.handle.net/10057/12569
dc.descriptionWSU inventor: William C. Groutas, Dept. of Chemistry, College of Liberal Arts and Sciences
dc.descriptionAppl. No.: 14/398,290 filed May 2, 2013
dc.description.abstractAntiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, sapoviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.
dc.format.extent26 claims; 10 drawing sheets; 31 pages.
dc.languageen_US
dc.publisherUnited States Patent and Trademark Office
dc.rightsStatus: Active; Anticipated expiration: 2032-09-27
dc.subject.classificationCPC: A61K 31/4192 (20130101); C07K 5/0821 (20130101); C07K 5/06139 (20130101); A61K 45/06 (20130101); A61K 31/454 (20130101); A61K 31/675 (20130101); A61K 38/05 (20130101); A61K 38/07 (20130101); C07K 5/06026 (20130101); C07K 5/1008 (20130101); A61K 38/00 (20130101); A61K 38/005 (20130101)
dc.subject.classificationIPC.: A61K 38/07 (20060101); C07K 5/078 (20060101); C07K 5/097 (20060101); A61K 31/675 (20060101); A61K 31/454 (20060101); A61K 45/06 (20060101); C07K 5/062 (20060101); C07K 5/103 (20060101); A61K 38/05 (20060101); A61K 31/4192 (20060101); A61K 38/00 (20060101)
dc.titleMacrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
dc.typePatent


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