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    Latent isocynate derivatives useful for deactivating enzymes

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    U.S. 4,929,736 (683.8Kb)
    Date
    1990-05-29
    Author
    Groutas, William C.
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    Citation
    Groutas, William C., inventor. Board of Trustees of the Wichita State University, assignee. Latent isocynate derivatives useful for deactivating enzymes. United States patent US 4,929,736. 1990, May 29.
    Abstract
    Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norleucine, and L-methionine methyl ester azolides succinimides or pyridones and sulfonate salts, and related compounds such as L-leucine and L-phenylalanine methyl ester derivatives. The compounds were found to be excellent inhibitors in that they embody both inhibitory and anti-oxidant or anti-inflammatory activity.
    Description
    WSU inventor: William C. Groutas, Dept. of Chemistry, College of Liberal Arts and Sciences

    Appl. No: 07/117,531 filed Nov 6, 1987. Patent No:. U.S. 4,929,736 granted May 29, 1990.
    URI
    https://patentimages.storage.googleapis.com/24/0d/2e/bdddbeb3a65e87/US4929736.pdf
    http://hdl.handle.net/10057/12557
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