Latent isocynate derivatives useful for deactivating enzymes
Groutas, William C.
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Groutas, William C., inventor. Board of Trustees of the Wichita State University, assignee. Latent isocynate derivatives useful for deactivating enzymes. United States patent US 4,929,736. 1990, May 29.
Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norleucine, and L-methionine methyl ester azolides succinimides or pyridones and sulfonate salts, and related compounds such as L-leucine and L-phenylalanine methyl ester derivatives. The compounds were found to be excellent inhibitors in that they embody both inhibitory and anti-oxidant or anti-inflammatory activity.
WSU inventor: William C. Groutas, Dept. of Chemistry, College of Liberal Arts and Sciences
Appl. No: 07/117,531 filed Nov 6, 1987. Patent No:. U.S. 4,929,736 granted May 29, 1990.