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dc.contributorKansas State University Research Foundation
dc.contributorOhio State University
dc.contributorWichita State University
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorKim, Yunjeong
dc.contributor.authorGroutas, William C.
dc.contributor.authorHua, Duy
dc.contributor.authorSaif, Linda J.
dc.date.accessioned2016-11-05T23:59:35Z
dc.date.available2016-11-05T23:59:35Z
dc.date.issued2016-10-25
dc.date.submitted2012-09-27
dc.identifierUS 9,474,759 B2
dc.identifier.citationChang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C; Hua, Duy; Saif, Linda J., inventors. Kansas State University Research Foundation (Manhattan, KS), The Ohio State University (Columbus, OH), Wichita State University (Wichita, KS), assignees. Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses. United States patent US 9,474,759. 2016, Oct 25.en_US
dc.identifier.urihttp://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=9,474,759.PN.&OS=PN/9,474,759&RS=PN/9,474,759
dc.identifier.urihttp://hdl.handle.net/10057/12553
dc.descriptionWSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences.en_US
dc.descriptionApplication No.: 14/347,756 filed September 27, 2012. Patent No.: US 9,474,759 granted October 25, 2016.
dc.description.abstractAntiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection and disease. The compounds possess broad-spectrum activity against viruses that belong to the picornavirus-like supercluster, which include important human and animal pathogens including noroviruses, enteroviruses, poliovirus, foot-and-mouth disease virus, hepatitis A virus, human rhinovirus (cause of common cold), human coronavirus (another cause of common cold), transmissible gastroenteritis virus, murine hepatitis virus, feline infectious peritonitis virus, and severe acute respiratory syndrome coronavirus.en_US
dc.format.extent20 claims; 23 drawing sheets; 55 pages
dc.language.isoenen_US
dc.publisherUnited States Patent and Trademark Officeen_US
dc.rightsOpen Access
dc.subject.classificationCPC: A61K 31/4015 (20130101); A61K 31/422 (20130101); A61K 31/427 (20130101); A61K 31/5377 (20130101); A61K 45/06 (20130101); C07D 207/27 (20130101); A61K 38/06 (20130101); C12N 2770/16011 (20130101); C12N 2770/20011 (20130101); C12N 2770/32111 (20130101); C12N 2770/32311 (20130101); C12N 2770/32411 (20130101); C12N 2770/32611 (20130101)
dc.subject.classificationIPC: A61K 38/06 (20060101); A61K 31/5377 (20060101); A61K 31/4015 (20060101); A61K 31/422 (20060101); A61K 31/427 (20060101); A61K 45/06 (20060101); C07D 207/27 (20060101)
dc.titleBroad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronavirusesen_US
dc.typePatenten_US


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