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Now showing items 1-20 of 146

    • Amino acid derivatives useful for deactivating enzymes 

      Groutas, William C. (European Patent Office, 1987-01-28)
      Certain amino-acid derivatives having three or four carbon straight alkyl chains are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme ...
    • Latent isocynate derivatives useful for deactivating enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
      Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
    • Novel serine protease inhibitors: Derivatives of isothiazolidin-3-one-1,1 dioxide and 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide 

      Groutas, William C. (World Intellectual Property Organization, 1995-07-13)
      Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
    • Serine protease inhibitors 

      Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
      Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
    • Novel serine protease inhibitors: Derivatives of isothiazolidin-3-one-1,1 dioxide and 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide 

      Groutas, William C. (European Patent Office, 1996-10-30)
      Abstract not available for EP0739338A1. Abstract of corresponding document: WO9518797A1: Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide and derivatives thereof, reduce or inhibit the activity ...
    • 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (World Intellectual Property Organization, 1999-03-04)
      Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them, are disclosed.
    • 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (European Patent Office, 2000-06-28)
      Abstract not available for EP1011668A1. Abstract of corresponding document: WO9909977A1; Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them, are disclosed.
    • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

      Groutas, William C. (World Intellectual Property Organization, 2001-11-01)
      Compounds of the general formula (I) are provided, and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or Ri capable of binding at a primary specificity site of a protease; Y is a chemical species ...
    • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
      Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
    • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
      Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
    • 1,2-benzisothiazolinone and isoindolinone derivatives 

      Calderone, Richard; Groutas, William C.; Korba, Brent E. (World Intellectual Property Organization, 2010-04-08)
      Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections ...
    • Viral and fungal inhibitors 

      Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E. (World Intellectual Property Organization, 2010-04-08)
      Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...
    • Protective antigen having fluorinated histidine residues 

      Bann, James G. (United States Patent and Trademark Office, 2010-06-08)
      The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ...
    • System and method for capturing image sequences at ultra-high framing rates 

      Madhavan, Viswanathan; Hijazi, Ala (United States Patent and Trademark Office, 2010-08-17)
      An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ...
    • Amino acid derived ureas 

      Korba, Brent E.; Groutas, William C. (World Intellectual Property Organization, 2010-12-29)
      Novel classes of amino acid derived urea compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus.
    • Friction stir welding tool having a counterflow pin configuration 

      Burford, Dwight A. (United States Patent and Trademark Office, 2011-05-17)
      A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ...
    • 1,2-benzisothiazolinone and isoindolinone derivatives 

      Calderone, Richard; Groutas, William C.; Korba, Brent E. (European Patent Office, 2011-07-20)
      Abstract not available for EP2344479A2. Abstract of corresponding document: WO2010039545A2: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions ...
    • Friction stir welding tool having a scroll-free concentric region 

      Burford, Dwight A. (United States Patent and Trademark Office, 2011-09-13)
      A friction stir welding tool having a shoulder section with a scroll pattern that terminates prior to the edge or boundary of the shoulder section to create a scroll-free concentric surface area.
    • Composite magnetic nanoparticle drug delivery system 

      Asmatulu, Ramazan; Misak, Heath Edward; Yang, Shang-You; Wooley, Paul H. (World Intellectual Property Organization, 2012-04-19)
      A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable ...
    • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: Picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy H.; Saif, Linda J. (World Intellectual Property Organization, 2013-04-04)
      Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl ?-ketoamides, peptidyl bisulfite salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the same ...