Now showing items 1-20 of 34

    • Latent isocynate derivatives useful for deactivating enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
      Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
    • Serine protease inhibitors 

      Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
      Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
    • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
      Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
    • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
      Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
    • Protective antigen having fluorinated histidine residues 

      Bann, James G. (United States Patent and Trademark Office, 2010-06-08)
      The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ...
    • System and method for capturing image sequences at ultra-high framing rates 

      Madhavan, Viswanathan; Hijazi, Ala (United States Patent and Trademark Office, 2010-08-17)
      An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ...
    • Friction stir welding tool having a counterflow pin configuration 

      Burford, Dwight A. (United States Patent and Trademark Office, 2011-05-17)
      A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ...
    • Friction stir welding tool having a scroll-free concentric region 

      Burford, Dwight A. (United States Patent and Trademark Office, 2011-09-13)
      A friction stir welding tool having a shoulder section with a scroll pattern that terminates prior to the edge or boundary of the shoulder section to create a scroll-free concentric surface area.
    • End effector for forming swept friction stir spot welds 

      Burford, Dwight A. (United States Patent and Trademark Office, 2013-05-21)
      An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
    • Viral and fungal inhibitors 

      Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E (United States Patent and Trademark Office, 2013-08-20)
      Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...
    • Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films 

      Dowling, Matthew; Raghavan, Srinivasa R.; Dashaputre, Neeraja; English, Douglas S.; Javvaji, Vishal; Payne, Gregory F.; DeShong, Philip R. (United States Patent and Trademark Office, 2014-10-14)
      A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle ...
    • End effector for forming swept friction stir spot welds 

      Burford, Dwight A. (United States Patent and Trademark Office, 2015-09-15)
      An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder.
    • Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2016-04-12)
      Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ...
    • Energy absorbing seat mechanism 

      Olivares, Gerardo (United States Patent and Trademark Office, 2016-05-03)
      A system includes a shear member and an energy absorber. The shear member is configured to couple a seat portion to a base structure of a vehicle. The shear member is configured to sustain a first load without fracture and ...
    • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy; Saif, Linda J. (United States Patent and Trademark Office, 2016-10-25)
      Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...
    • System and method for generating exact symbol error rates of frequency-hopped signals 

      Kwon, Hyuck M.; Pham, Khanh D. (United States Patent and Trademark Office, 2017-08-22)
      A system and method for transmitting data over a wireless communication network. The method broadly includes generating a frequency hopping pattern spanning a plurality of time hops and a plurality of signal frequencies; ...
    • System and method for recycling of pre-impregnated composite fibers 

      Asmatulu, Ramazan; Patlolla, Vamsidhar Reddy (United States Patent and Trademark Office, 2017-10-03)
      An apparatus for recycling of fibers pre-impregnated with resin may include a container configured to receive a predetermined amount of solvent and a predetermined amount of fibers pre-impregnated with resin. The apparatus ...
    • Composite magnetic nanoparticle drug delivery system 

      Asmatulu, Ramazan; Misak, Heath Edward; Yang, Shang-You; Wooley, Paul H. (United States Patent and Trademark Office, 2017-10-10)
      A composite magnetic nanoparticle drug delivery system provides targeted controlled release chemotherapies for cancerous tumors and inflammatory diseases. The magnetic nanoparticle includes a biocompatible and biodegradable ...
    • Vehicle operator impairment detection system and method 

      He, Jibo; Ren, Zhiquan (United States Patent and Trademark Office, 2017-11-07)
      An operator impairment detection system comprising a wearable mobile device including a frame for supporting the wearable mobile device on an operator's face, an accelerometer for sensing acceleration of the wearable mobile ...
    • System and method for channel probability mass function dependent frequency hopping 

      Kwon, Hyuck M.; Hannon, Matthew; Pham, Khanh D. (United States Patent and Trademark Office, 2017-11-14)
      A system and method for generating a channel statistics dependent frequency hopping pattern that requires low computational complexity and simultaneously maximizes channel capacity and minimizes the symbol error rate or ...