Now showing items 1-9 of 9

    • 1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives 

      Groutas, William C.; Kuang, Rongze (United States Patent and Trademark Office, 2002-07-16)
      Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them.
    • Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C.; Hua, Duy; Saif, Linda J. (United States Patent and Trademark Office, 2016-10-25)
      Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...
    • Latent isocynate derivatives useful for deactivating enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 1990-05-29)
      Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ...
    • Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2016-04-12)
      Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ...
    • Protease transition state inhibitor prodrugs 

      Chang, Kyeong-Ok; Groutas, William C. (United States Patent and Trademark Office, 2021-06-15)
      Disclosed herein are protease transition state inhibitor/analogue prodrug compounds selected from the group consisting of esters, carbamates, ester phosphates, and pharmaceutically acceptable salts thereof. Compositions ...
    • Serine protease inhibitors 

      Groutas, William C. (United States Patent and Trademark Office, 1996-08-27)
      Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents.
    • Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses 

      Chang, Kyeong-Ok; Kim, Yunjeong; Groutas, William C. (United States Patent and Trademark Office, 2021-05-25)
      Antiviral protease inhibitors are disclosed, along with related antiviral dipeptidyl compounds, macrocyclic derivatives thereof and methods of using the same to treat or prevent viral infection and disease from coronaviruses, ...
    • Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes 

      Groutas, William C. (United States Patent and Trademark Office, 2002-12-17)
      Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ...
    • Viral and fungal inhibitors 

      Padmanabhan, Radhakrishnan; Groutas, William C.; Korba, Brent E (United States Patent and Trademark Office, 2013-08-20)
      Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ...