Wichita State Patents
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Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-04-12)Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ... -
End effector for forming swept friction stir spot welds
(United States Patent and Trademark Office, 2015-09-15)An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder. -
Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
(United States Patent and Trademark Office, 2002-12-17)Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ... -
Protective antigen having fluorinated histidine residues
(United States Patent and Trademark Office, 2010-06-08)The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ... -
System and method for capturing image sequences at ultra-high framing rates
(United States Patent and Trademark Office, 2010-08-17)An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ... -
Latent isocynate derivatives useful for deactivating enzymes
(United States Patent and Trademark Office, 1990-05-29)Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ... -
Friction stir welding tool having a counterflow pin configuration
(United States Patent and Trademark Office, 2011-05-17)A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ... -
Serine protease inhibitors
(United States Patent and Trademark Office, 1996-08-27)Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents. -
1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
(United States Patent and Trademark Office, 2002-07-16)Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them. -
Friction stir welding tool having a scroll-free concentric region
(United States Patent and Trademark Office, 2011-09-13)A friction stir welding tool having a shoulder section with a scroll pattern that terminates prior to the edge or boundary of the shoulder section to create a scroll-free concentric surface area. -
End effector for forming swept friction stir spot welds
(United States Patent and Trademark Office, 2013-05-21)An apparatus includes a connector and is configured to mount to a machine having multiple axes of control. A control signal on the connector determines a path of a rotating tool holder. -
Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films
(United States Patent and Trademark Office, 2014-10-14)A biosensor comprising an electrically conductive substrate coated with a modified chitosan biopolymer that has been electrodeposited on the substrate, wherein said modified chitosan biopolymer comprises at least one vesicle ... -
Viral and fungal inhibitors
(United States Patent and Trademark Office, 2013-08-20)Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ... -
Energy absorbing seat mechanism
(United States Patent and Trademark Office, 2016-05-03)A system includes a shear member and an energy absorber. The shear member is configured to couple a seat portion to a base structure of a vehicle. The shear member is configured to sustain a first load without fracture and ... -
Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-10-25)Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl .alpha.-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and methods of using the ...
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