Browsing Office of Research by Issue Date
Now showing items 1-20 of 251
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Amino acid derivatives useful for deactivating enzymes
(European Patent Office, 1987-01-28)Certain amino-acid derivatives having three or four carbon straight alkyl chains are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme ... -
Latent isocynate derivatives useful for deactivating enzymes
(United States Patent and Trademark Office, 1990-05-29)Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ... -
Novel serine protease inhibitors: Derivatives of isothiazolidin-3-one-1,1 dioxide and 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide
(World Intellectual Property Organization, 1995-07-13)Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents. -
Serine protease inhibitors
(United States Patent and Trademark Office, 1996-08-27)Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents. -
Novel serine protease inhibitors: Derivatives of isothiazolidin-3-one-1,1 dioxide and 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide
(European Patent Office, 1996-10-30)Abstract not available for EP0739338A1. Abstract of corresponding document: WO9518797A1: Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1-dioxide and derivatives thereof, reduce or inhibit the activity ... -
1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
(World Intellectual Property Organization, 1999-03-04)Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them, are disclosed. -
1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
(European Patent Office, 2000-06-28)Abstract not available for EP1011668A1. Abstract of corresponding document: WO9909977A1; Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them, are disclosed. -
Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
(World Intellectual Property Organization, 2001-11-01)Compounds of the general formula (I) are provided, and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or Ri capable of binding at a primary specificity site of a protease; Y is a chemical species ... -
1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
(United States Patent and Trademark Office, 2002-07-16)Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them. -
Sulfamide and bis-sulfamide amino acid derivatives as inhibitors of proteolytic enzymes
(United States Patent and Trademark Office, 2002-12-17)Compounds of the general formula I are provided: ##STR1## and pharmaceutically acceptable salts thereof, wherein, Z is a chemical species or R.sub.i capable of binding at a primary specificity site of a protease; Y is a ... -
Performance evaluation of child safety seats in far-side lateral sled tests at varying speeds
(Association for the Advancement of Automotive Medicine, 2009-10-05)Protection of children in Child Safety Seats (CSS) in side impact crashes has been a topic of recent studies. The objective of this study was to evaluate the performance of CSS in far-side impacts through a series of sled ... -
ACG MTM45-1: Material Model Development Final Project Wrap-Up
(Wichita State University. National Institute for Aviation Research, 2009-11-15)National Center for Advanced Material Performance document prepared by: A. Shahkarami and D. Van Ee. Reviewed by: D. Van Ee Approved: A.Poursartip. Date: November 15th, 2009 Version: 1.0 -
1,2-benzisothiazolinone and isoindolinone derivatives
(World Intellectual Property Organization, 2010-04-08)Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral, yeast, and fungal infections ... -
Viral and fungal inhibitors
(World Intellectual Property Organization, 2010-04-08)Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ... -
Protective antigen having fluorinated histidine residues
(United States Patent and Trademark Office, 2010-06-08)The unnatural amino acid analogue 2-fluorohistidine (2-FHis) was incorporated into protective antigen to produce a protein which resists protonation at physiological pH by reducing the side-chain pKa. The protein structure ... -
System and method for capturing image sequences at ultra-high framing rates
(United States Patent and Trademark Office, 2010-08-17)An imaging system for capturing a sequence of images from a target at ultra-high framing rates is disclosed. The imaging system includes an illumination system operable to emit at least first and second light pulses at ... -
Amino acid derived ureas
(World Intellectual Property Organization, 2010-12-29)Novel classes of amino acid derived urea compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus. -
SPH -- Lagrangian study of bird impact on leading edge wing
(Elsevier, 2011-02)Results from the experimental tests are given so that they can be used to validate numerical models and promote the use of the numerical tools in aircraft design and certification process. The explicit finite element ... -
Friction stir welding tool having a counterflow pin configuration
(United States Patent and Trademark Office, 2011-05-17)A friction stir welding tool having one or more tapered flats for promoting flow of weld material toward the pin terminus and one or more counter-spiraling channels or threads which for promoting flow of the weld material ... -
1,2-benzisothiazolinone and isoindolinone derivatives
(European Patent Office, 2011-07-20)Abstract not available for EP2344479A2. Abstract of corresponding document: WO2010039545A2: Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions ...