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dc.contributor.authorYao, Li
dc.contributor.authorLi, Yongchao
dc.identifier.citationYao, Li; Li, Yongchao. 2016. The role of direct current electric field-guided stem cell migration in neural regeneration. Stem Cell Reviews and Reports, vol. 12:no. 3:pp 365-375en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractEffective directional axonal growth and neural cell migration are crucial in the neural regeneration of the central nervous system (CNS). Endogenous currents have been detected in many developing nervous systems. Experiments have demonstrated that applied direct current (DC) electric fields (EFs) can guide axonal growth in vitro, and attempts have been made to enhance the regrowth of damaged spinal cord axons using DC EFs in in vivo experiments. Recent work has revealed that the migration of stem cells and stem cell-derived neural cells can be guided by DC EFs. These studies have raised the possibility that endogenous and applied DC EFs can be used to direct neural tissue regeneration. Although the mechanism of EF-directed axonal growth and cell migration has not been fully understood, studies have shown that the polarization of cell membrane proteins and the activation of intracellular signaling molecules are involved in the process. The application of EFs is a promising biotechnology for regeneration of the CNS.en_US
dc.publisherSpringer International Publishing AGen_US
dc.relation.ispartofseriesStem Cell Reviews and Reports;v.12:no.3
dc.subjectStem cellsen_US
dc.subjectElectric fieldsen_US
dc.subjectNeural regenerationen_US
dc.titleThe role of direct current electric field-guided stem cell migration in neural regenerationen_US
dc.rights.holderCopyright © 2016, Springer Science+Business Media New Yorken_US

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