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dc.contributor.authorSteinke, Elaine E.
dc.contributor.authorJohansen, Pernille Palm
dc.contributor.authorFridlund, Bengt G. A.
dc.contributor.authorBrostrom, A.
dc.date.accessioned2016-03-29T15:40:46Z
dc.date.available2016-03-29T15:40:46Z
dc.date.issued2016-01
dc.identifier.citationSteinke, E., Palm Johansen, P., Fridlund, B. and Broström, A. (2016), Determinants of sexual dysfunction and interventions for patients with obstructive sleep apnoea: a systematic review. International Journal of Clinical Practice, 70: 5–19. doi: 10.1111/ijcp.12751en_US
dc.identifier.issn1368-5031
dc.identifier.otherWOS:000371231100002
dc.identifier.urihttp://dx.doi.org/10.1111/ijcp.12751
dc.identifier.urihttp://hdl.handle.net/10057/11981
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractAims: Obstructive sleep apnoea (OSA) may negatively affect a couple's sexual relationship. This systematic review evaluated what characteristics are determinants of sexual function and dysfunction in women and men with OSA, and what interventions are shown to be effective. Methods: A systematic literature review was conducted using PubMed, CINAHL, Cochrane and TRIP, and articles published between January 2004 and December 2014 in English; original research; adults >= 18 years; and both experimental and non-experimental designs. The Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies was used to assess study quality. Of 21 studies, six studies (no randomised control trials, RCTs) included women and 15 (with six RCTs) studies included men. Extracted data were scrutinised and adjusted until consensus was reached; suitable quantitative data were pooled in statistical meta-analysis. Results: Sexual function was affected similarly in both genders, but effective interventions were reported only for men. In some studies, OSA severity and medications contributed to greater sexual dysfunction. In women, menopausal status, hormone levels and SaO(2) < 90% were determinants of sexual dysfunction, while for men factors included BMI, hormonal status and inflammatory markers. Continuous positive airway pressure (CPAP) not only improved clinical measures such as excessive daytime sleepiness but also the erectile and orgasmic function. Nevertheless, sildenafil was superior CPAP with regard to erectile dysfunction. Conclusions: The findings illustrate important contributors to sexual dysfunction; however, firm generalisations cannot be made. There were limited RCTs and none for women, indicating further RCTs are needed to determine how OSA affects sexual function.en_US
dc.language.isoen_USen_US
dc.publisherWiley Periodicals, Inc.en_US
dc.relation.ispartofseriesInternational Journal of Clinical Practice;v.70:no.1
dc.subjectPositive airway pressureen_US
dc.subjectErectile dysfunctionen_US
dc.subjectCPAP-treatmenten_US
dc.subjectWomenen_US
dc.subjectTherapyen_US
dc.subjectMenen_US
dc.subjectAdultsen_US
dc.subjectLifeen_US
dc.subjectPerspectiveen_US
dc.subjectPrevalenceen_US
dc.titleDeterminants of sexual dysfunction and interventions for patients with obstructive sleep apnoea: a systematic reviewen_US
dc.typeArticleen_US
dc.rights.holder© 2015 John Wiley & Sons Ltden_US


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