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dc.contributor.authorKim, Yunjeong
dc.contributor.authorKankanamalage, Anushka C. Galasiti
dc.contributor.authorDamalanka, Vishnu C.
dc.contributor.authorWeerawarna, Pathum M.
dc.contributor.authorGroutas, William C.
dc.contributor.authorChang, Kyeong-Ok
dc.identifier.citationYunjeong KimAnushka C. Galasiti KankanamalageVishnu C. DamalankaPathum M. WeerawarnaWilliam C. GroutasKyeong-Ok Chang. 2016. Potent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and α-ketoamides. Antiviral Research January 2016, Vol.125:84–91, doi:10.1016/j.antiviral.2015.11.010en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractEnterovirus D68 (EV-D68) is an emerging pathogen responsible for mild to severe respiratory infections that occur mostly in infants, children and teenagers. EV-D68, one of more than 100 non-polio enteroviruses, is acid-labile and biologically similar to human rhinoviruses (HRV) (originally classified as HRV87). However, there is no approved preventive or therapeutic measure against EV-D68, HRV, or other enteroviruses. In this study, we evaluated the antiviral activity of series of dipeptidyl compounds against EV-D68 and HRV strains, and demonstrated that several peptidyl aldehyde and alpha-ketoamide peptidyl compounds are potent inhibitors of EV-D68 and HRV strains with high in-vitro therapeutic indices (>1000). One of the alpha-ketoamide compounds is shown to have favorable pharmacokinetics profiles, including a favorable oral bioavailability in rats. Recent successful development of alpha-ketoamide protease inhibitors against hepatitis C virus suggests these compounds may have a high potential for further optimization and development against emerging EV-D68, as well as HRV. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipNIH grant (R01AI109039).en_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofseriesAntiviral Research;v.125
dc.subjectEnterovirus D68en_US
dc.subjectHuman rhinovirusen_US
dc.subjectAldehyde and alpha-ketoamide peptidyl compoundsen_US
dc.titlePotent inhibition of enterovirus D68 and human rhinoviruses by dipeptidyl aldehydes and alpha-ketoamidesen_US
dc.rights.holder(C) 2015 Elsevier B.V. All rights reserved.en_US

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