Show simple item record

dc.contributor.authorKim, Yunjeong
dc.contributor.authorGalasiti Kankanamalage, Anushka Chathuranga
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorGroutas, William C.
dc.date.accessioned2016-01-31T22:50:34Z
dc.date.available2016-01-31T22:50:34Z
dc.date.issued2015-12-24
dc.identifier.citationYunjeong Kim, Anushka C. Galasiti Kankanamalage, Kyeong-Ok Chang, and William C. Groutas. Recent advances in the discovery of norovirus therapeutics. Journal of Medicinal Chemistry 2015 58 (24), 9438-9450en_US
dc.identifier.issn0022-2623
dc.identifier.otherWOS:000367563100002
dc.identifier.urihttp://dx.doi.org/10.1021/acs.jmedchem.5b00762
dc.identifier.urihttp://hdl.handle.net/10057/11731
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractNoroviruses are members of the family Caliciviridae. Norovirus infections are a global health burden that impacts >20 million individuals annually in the U.S. alone. Noroviruses are associated with high morbidity among vulnerable populations, particularly immunocompromised patients. This perspective highlights recent developments related to the discovery and development of norovirus-specific small-molecule therapeutics as well as recent advances in our understanding of norovirus biology and pathogenesis. Most Of the work in this area is at the early discovery stage and has been primarily focused On inhibitors of norovirus 3C-like protease and RNA dependent RNA polymerase. However, recent discoveries emanating from basic studies in norovirus research have resulted in the identification of new host-related drug targets that can be exploited. A repurposed compound has been advanced to human clinical studies.en_US
dc.description.sponsorshipNational Institutes of Health (R0IAI109039).en_US
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofseriesJournal of Medicinal Chemistry;v.58:no.24
dc.subjectDependent rna-polymeraseen_US
dc.subjectGroup antigen receptorsen_US
dc.subjectRecognize beta-strandsen_US
dc.subjectNorwalk-virusen_US
dc.subjectCapsid proteinen_US
dc.subjectMurine norovirusen_US
dc.subjectPotent inhibitionen_US
dc.subjectSubstrate-specificityen_US
dc.subjectViral gastroenteritisen_US
dc.subjectCrystal-structuresen_US
dc.titleRecent advances in the discovery of norovirus therapeuticsen_US
dc.typeArticleen_US
dc.rights.holderCopyright © 2015 American Chemical Societyen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record