Palladin Nucleates Actin Assembly and Regulates Cytoskeleton Architecture
Beck, Moriah R.
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Gurung, Ritu; Vattepu, Ravi; Yadav, Rahul; Beck, Moriah R. 2015. Palladin Nucleates Actin Assembly and Regulates Cytoskeleton Architecture. Biophysical Journal, vol. 108:no. 2, Supplement 1, 27 January 2015:pp 297a
The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the coordinated regulation of actin dynamics. Palladin localizes to actin-rich protrusions and has a well-documented effect on metastasis of invasive cancers. However, its potential effects on actin dynamics have remained elusive. Here, we show that the C-terminal immunoglobulin-like domain of palladin (Ig3) that is directly responsible for actin binding and bundling also potently nucleates the formation of actin filaments in vitro.
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