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dc.contributor.authorVeisi, Zeinab
dc.contributor.authorCeylan, Muhammet
dc.contributor.authorMahapatro, Anil
dc.contributor.authorAsmatulu, Ramazan
dc.date.accessioned2015-09-14T19:22:47Z
dc.date.available2015-09-14T19:22:47Z
dc.date.issued2014
dc.identifier.citationVeisi, Zeinab; Ceylan, Muhammet; Mahapatro, Anil; Asmatulu, Ramazan. 2014. An electrospun polyaniline nanofiber as a novel platform for real-time COX-2 biomarker detection. Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exhibition (IMECE2013), vol. 3Ben_US
dc.identifier.isbn978-0-7918-5622-2
dc.identifier.otherWOS:000359682500028
dc.identifier.urihttps://dx.doi.org/10.1115/IMECE2013-65269
dc.identifier.urihttp://hdl.handle.net/10057/11519
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractThe presence of Cyclooxygenase-2 (COX-2) biomarker has been associated with the development of certain types of cancer such as breast cancer. Moreover, reliable quantification of COX-2 as an enzyme responsible for pain and inflammation is vital. Here we demonstrate the feasibility of sensitive COX-2 detection via integration of nanoporous polyaniline fibers on the microfabricated platform to develop a label-free biosensor. Highly porous polyaniline nanofibers were fabricated in different diameters and integrated on the interdigitated microelectrodes to develop electrochemical platforms. Characterization results revealed that the smaller diameter improved the sensitivity of the biosensor due to enhancement in the specific surface area. The developed biosensor was able to detect analyte as low as 0.1 pg/mL with a large dynamic linear range of 10 fg/mL to 1 mu g/mL. The fabricated sensor showed remarkable sensitivity towards COX-2 antigen suggesting the significant contribution of this nanofiber based platform to the enhanced sensitivity in COX-2 analyte detection.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Mechanical Engineersen_US
dc.relation.ispartofseriesProceedings of the ASME 2013 International Mechanical Engineering Congress and Exhibition (IMECE2013);v.3B
dc.subjectCanceren_US
dc.subjectCyclooxygenase-2en_US
dc.subjectCellsen_US
dc.subjectBiosensoren_US
dc.subjectPathwayen_US
dc.subjectTargeten_US
dc.subjectKeyen_US
dc.titleAn electrospun polyaniline nanofiber as a novel platform for real-time COX-2 biomarker detectionen_US
dc.typeConference paperen_US
dc.rights.holder© The American Society of Mechanical Engineers


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