Show simple item record

dc.contributor.authorSaeednia, Leyla
dc.contributor.authorUsta, Aybala
dc.contributor.authorAsmatulu, Ramazan
dc.date.accessioned2015-09-14T15:59:33Z
dc.date.available2015-09-14T15:59:33Z
dc.date.issued2014
dc.identifier.citationSaeednia, Leyla; Usta, Aybala; Asmatulu, Ramazan. 2014. Preparation and characterization of drug-loaded thermosensitive hydrogels. Proceedings of the ASME 2013 International Mechanical Engineering Congress and Exhibition (IMECE2013), vol. 3:Parts A&B: Biomedical and Biotechnology Engineering,en_US
dc.identifier.isbn978-0-7918-5622-2
dc.identifier.otherWOS:000359682500023
dc.identifier.urihttps://dx.doi.org/10.1115/IMECE2013-66489
dc.identifier.urihttp://hdl.handle.net/10057/11516
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractHydrogels are the promising classes of polymeric drug delivery systems with the controlled release rates. Among them, injectable thermosensitive hydrogels with transition temperature around the body temperature have been wildly considered. Chitosan is one of the most abundant natural polymers, and its biocompatibility and biodegradability makes it a favorable thermosensitive hydrogel that has been attracted much attention in biomedical field worldwide. In this work, a thermosensitive and injectable hydrogel was prepared using chitosan and beta-glycerophosphate (beta-GP) incorporated with an antibacterial drug (gentamycin). This drug loaded hydrogel is liquid at room temperature, and becomes more solidified gel when heated to the body temperature. Adding beta-GP into chitosan and drug molecules and heating the overall solution makes the whole homogenous liquid into gel through a 3D network formation. The gelation time was found to be a function of temperature and concentration of beta-GP. This thermosensitive chitosan based hydrogel system was characterized using FTIR and visual observation to determine the chemical structure and morphology. The results confirmed that chitosan / (beta-GP) hydrogels could be a promising controlled-release drug delivery system for many deadly diseases.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Mechanical Engineersen_US
dc.relation.ispartofseriesProceedings of the ASME 2013 International Mechanical Engineering Congress and Exhibition (IMECE2013);v.3B
dc.subjectChitosanen_US
dc.subjectBeta-glycerophosphateen_US
dc.subjectDrugen_US
dc.subjectHydrogelen_US
dc.subjectThermosensitivityen_US
dc.subjectDrug Releaseen_US
dc.titlePreparation and characterization of drug-loaded thermosensitive hydrogelsen_US
dc.typeConference paperen_US
dc.rights.holder© 2015 ASME The American Society of Mechanical Engineers


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record