Assessment of arterial function recovery after surgical revascularization in PAD patients with micro-vascular insufficiency using computational model analysis
Date
2015-04-24Author
Jayakumar, Balakumar
Mehraein, Hootan
Advisor
Cluff, KimMetadata
Show full item recordCitation
Jayakumar, Balakumar. Assessment of Arterial Function Recovery after Surgical Revascularization in PAD Patients with Micro-Vascular Insufficiency using Computational Model Analysis. --In Proceedings: 11th Annual Symposium on Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 52
Abstract
Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries
supplying blood to the lower extremities, which cause a progressive accumulation of ischemic
injury. Despite revascularization treatment intervention some PAD patients require follow up
secondary treatment due to a continued decline in limb function, quality of life and walking
parameters. Standard revascularization surgical procedures restore blood flow in the main
arteries via bypass surgical grafting. Nutrient transport and oxygen transfer take place at the level
of the microvasculature and capillaries. However, an assessment of the microvascular circulation
is lacking. Microvascular dysfunction, a 'no flow' phenomena that may occur at the level of
microvasculature, may impair tissue oxygenation as well as nutrient transport and may therefore
be a contributor to the continued decline in limb function and walking parameters. Microvascular
dysfunction may be one of the dominating factors to be studied to understand the failure of the
arterial function recovery. Multi-physics simulation software was used to model the phenomena
to assess the effectiveness of the standard lower limb revascularization treatment in PAD patients
who may have microvascular dysfunction. Typical invasive revascularization surgery using
artificial bypass grafts to restore blood flow may fail to be effective if the PAD patient has
microvascular dysfunction. This model identifies the need to measure the microvascular
circulation in the compromised limbs of PAD patients to optimize diagnosis and treatment
strategies that reflect the underlying pathophysiology.
Description
Presented to the 11th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Heskett Center, Wichita State University, April 24, 2015.
Research completed at Department of Industrial and Manufacturing Engineering, College of Engineering & Department of Biomedical Engineering, College of Engineering