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dc.contributor.authorAbedin, Farhana
dc.contributor.authorAnwar, Md. Rajib
dc.contributor.authorAsmatulu, Ramazan
dc.contributor.authorYang, Shang-You
dc.identifier.citationFarhana Abedin, Md R Anwar, Ramazan Asmatulu, and Shang-You Yang Albumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatment J Biomater Appl July 2015 30: 38-49, first published on January 30, 2015en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractAlbumin-based drug-carrying micro-composite spheres were fabricated and studied to evaluate their potentials for breast cancer treatment. Magnetic nanoparticles and albumin were incorporated within poly(D l-lactide-co-glycolide) microspheres to increase accumulation of the microspheres at the target site. Two chemotherapeutics, cyclophosphamide and 5-fluorouracil, were encapsulated into the microspheres. The drug-release study revealed an initial burst of drug and then sustained release by diffusion. A Fourier transform infrared spectroscopy study confirmed the presence of all components of the drug delivery system. An in vitro study using fibroblast cells (3T3) and breast cancer cells (MDA-486) exhibited an effective cytotoxicity behavior when exposed to the drug delivery system in a dose- and time-dependent manner. The therapeutic influence of the drug delivery system was evaluated in vivo using a nude mouse breast cancer model. A continuous decrease in tumor size was observed in groups treated with microspheres containing the chemotherapeutics, whereas mice treated with direct chemotherapy without drug delivery system showed less efficacy and suggested tumor relapse after cessation of treatment. The enhanced therapeutic influence of the drug delivery system may be attributed to the increased uptake of the microspheres by malignant cells due to the presence of albumin and magnetic force. The bioavailability of chemotherapeutics at the target site was further increased due to the sustained release of the drugs by diffusion following the burst release. Continuous investigations will optimize the size of the drug delivery system and portions of the target driving-force components (magnetic nanoparticles and albumin) in the drug delivery system to maximize its therapeutic efficacy and minimize potential long-term side effects.en_US
dc.description.sponsorshipThe authors greatly acknowledge the Flossie West Foundation and Wichita State University for the financial support of the present work.en_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofseriesJournal of Biomaterials Applications;v.30:no.1
dc.subjectDrug deliveryen_US
dc.subjectMagnetic nanoparticlesen_US
dc.subjectBreast canceren_US
dc.subjectDrug releaseen_US
dc.titleAlbumin-based micro-composite drug carriers with dual chemo-agents for targeted breast cancer treatmenten_US
dc.rights.holderCopyright © 2015 by SAGE Publications

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