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dc.contributor.authorBai, Xia
dc.contributor.authorWang, Xiang
dc.contributor.authorEnglish, Douglas S.
dc.contributor.authorLee, Sang Bok
dc.identifier.citationBai, X., Wang, X., English, D. and Lee, S. B. (2015), Loading and Release of Doxorubicin with Magnetic Nanotubes#. Bulletin of the Korean Chemical Society, 36: 772–776. doi: 10.1002/bkcs.10141en_US
dc.descriptionClick on the URL to access this article (may not be free).en_US
dc.description.abstractIn this work, we study magnetic nanotubes (MNTs) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18-silane and pyridine-silane. By tuning the interaction between the drug molecules and inner surfaces of MNTs via pH, Dox can be effectively encapsulated at pH 7.2 and released at pH 4.5. The successful loading of Dox is confirmed with confocal microscopy studies. The release profiles of Dox from modified MNTs are detected by spectrofluorophotometry, with bare MNTs as control. With proper modifications, MNTs can be used for pH-dependent, controlled release of drug molecules.en_US
dc.description.sponsorshipPublication cost of this paper was supported by the Korean Chemical Society.en_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.relation.ispartofseriesBulletin of the Korean Chemical Society;v.36:no.3
dc.subjectMagnetic nanotubesen_US
dc.subjectSuperparamagnetic iron oxide nanoparticlesen_US
dc.subjectpH-dependent controlled releaseen_US
dc.titleLoading and release of doxorubicin with magnetic nanotubesen_US
dc.rights.holder© 2015 Korean Chemical Society, Seoul & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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