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dc.contributor.authorUnkelbach, Jan
dc.contributor.authorBortfeld, Thomas
dc.contributor.authorCraft, David
dc.contributor.authorAlber, Markus
dc.contributor.authorBangert, Mark
dc.contributor.authorBokrantz, Rasmus
dc.contributor.authorChen, Danny
dc.contributor.authorLi, Ruijiang
dc.contributor.authorXing, Lei
dc.contributor.authorMen, Chunhua
dc.contributor.authorNill, Simeon
dc.contributor.authorPapp, David
dc.contributor.authorRomeijn, Edwin
dc.contributor.authorSalari, Ehsan
dc.identifier.citationUnkelbach, Jan; Bortfeld, Thomas; Craft, David; Alber, Markus; Bangert, Mark; Bokrantz, Rasmus; Chen, Danny; Li, Ruijiang; Xing, Lei; Men, Chunhua; Nill, Simeon; Papp, David; Romeijn, Edwin; Salari, Ehsan. 2015. Optimization approaches to volumetric modulated arc therapy planning. Medical Physics, vol. 42:no. 3:pp 1367-1377en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractVolumetric modulated arc therapy (VMAT) has found widespread clinical application in recent years. A large number of treatment planning studies have evaluated the potential for VMAT for different disease sites based on the currently available commercial implementations of VMAT planning. In contrast, literature on the underlying mathematical optimization methods used in treatment planning is scarce. VMAT planning represents a challenging large scale optimization problem. In contrast to fluence map optimization in intensity-modulated radiotherapy planning for static beams, VMAT planning represents a nonconvex optimization problem. In this paper, the authors review the state-of-the-art in VMAT planning from an algorithmic perspective. Different approaches to VMAT optimization, including arc sequencing methods, extensions of direct aperture optimization, and direct optimization of leaf trajectories are reviewed. Their advantages and limitations are outlined and recommendations for improvements are discussed.en_US
dc.publisherAmerican Association of Physicists in Medicineen_US
dc.relation.ispartofseriesMedical Physics;v.42:no.3
dc.subjectTreatment plan optimizationen_US
dc.titleOptimization approaches to volumetric modulated arc therapy planningen_US
dc.rights.holder© 2015 American Association of Physicists in Medicine

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