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dc.contributor.authorShrestha, Bikesh
dc.contributor.authorCoykendall, Katherine
dc.contributor.authorLi, Yongchao
dc.contributor.authorMoon, Alex
dc.contributor.authorPriyadarshani, Priyanka
dc.contributor.authorYao, Li
dc.identifier.citationShrestha, Bikesh; Coykendall, Katherine; Li, Yongchao; Moon, Alex; Priyadarshani, Priyanka; Yao, Li. 2014. Repair of injured spinal cord using biomaterial scaffolds and stem cells. Stem Cell Research & Therapy 2014 Aug 1;5(4):91.en_US
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractThe loss of neurons and degeneration of axons after spinal cord injury result in the loss of sensory and motor functions. A bridging biomaterial construct that allows the axons to grow through has been investigated for the repair of injured spinal cord. Due to the hostility of the microenvironment in the lesion, multiple conditions need to be fulfilled to achieve improved functional recovery. A scaffold has been applied to bridge the gap of the lesion as contact guidance for axonal growth and to act as a vehicle to deliver stem cells in order to modify the microenvironment. Stem cells may improve functional recovery of the injured spinal cord by providing trophic support or directly replacing neurons and their support cells. Neural stem cells and mesenchymal stem cells have been seeded into biomaterial scaffolds and investigated for spinal cord regeneration. Both natural and synthetic biomaterials have increased stem cell survival in vivo by providing the cells with a controlled microenvironment in which cell growth and differentiation are facilitated. This optimal multi-disciplinary approach of combining biomaterials, stem cells, and biomolecules offers a promising treatment for the injured spinal cord.en_US
dc.description.sponsorshipWichita State University, the National Center for Research Resources (P20 RR016475), and the National Institute of General Medical Sciences (P20 GM103418) from the National Institutes of Health.en_US
dc.publisherBioMed Central Ltden_US
dc.relation.ispartofseriesStem Cell Research & Therapy;v.5:article91
dc.subjectTemplated agarose scaffoldsen_US
dc.subjectNeural stemen_US
dc.subjectFunctional recoveryen_US
dc.subjectAxonal regenerationen_US
dc.subjectNeurotrophic factoren_US
dc.subjectWallerian degenerationen_US
dc.subjectPromote regenerationen_US
dc.subjectNerve regenerationen_US
dc.titleRepair of injured spinal cord using biomaterial scaffolds and stem cellsen_US
dc.rights.holder© 2014 BioMed Central

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