• Login
    View Item 
    •   Shocker Open Access Repository Home
    • Graduate Student Research
    • GRASP: Graduate Research and Scholarly Projects
    • Proceedings 2014: 10th Annual Symposium on Graduate Research and Scholarly Projects
    • View Item
    •   Shocker Open Access Repository Home
    • Graduate Student Research
    • GRASP: Graduate Research and Scholarly Projects
    • Proceedings 2014: 10th Annual Symposium on Graduate Research and Scholarly Projects
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Expression of VEGF, CXCR4, and CD133 in osteosarcoma

    View/Open
    Conference paper (40.63Kb)
    Date
    2014-04-25
    Author
    Garcia, Elka S.
    Advisor
    Yang, Shang-You
    Metadata
    Show full item record
    Citation
    Garcia, Elka S. 2014. Expression of VEGF, CXCR4, and CD133 in Osteosarcoma. -- In Proceedings: 10th Annual Symposium on Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 22
    Abstract
    Osteosarcoma is the most common primary malignant bone tumor seen in orthopaedic practice. Despite intensive treatments of chemotherapy and surgical excision, the current five-year survival rate is only 60% to 78%. We are investigating the correlation of vascular endothelial growth factor (VEGF) expression with osteosarcoma growth and metastasis and trying to explore a therapeutic strategy by blocking VEGF. Recent studies have suggested that a subpopulation of cancer stem cells (CSCs) play a role in cancer survival and metastasis. The purpose of my project is to examine if regulating the function of VEGF can change the population of CSCs in osteosarcoma. Using polymerase chain reaction and immunocytochemistry techniques, we will examine the expression of VEGF, CXCR4 and cancer stem cell marker CD133 at transcriptional and post-translational levels among different VEGF-expressing osteosarcoma cells. We will examine the tumor cell growth patterns and compare the subpopulation ratio of CD133+ cells after VEGF blockage.
    Description
    Presented to the 10th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Heskett Center, Wichita State University, April 25, 2014.

    Research completed at the Department of Biological Sciences, College of Liberal Arts and Sciences
    URI
    http://hdl.handle.net/10057/10768
    Collections
    • BIO Graduate Student Conference Papers
    • Proceedings 2014: 10th Annual Symposium on Graduate Research and Scholarly Projects

    Browse

    All of Shocker Open Access RepositoryCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsBy TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsBy Type

    My Account

    LoginRegister

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV