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dc.contributor.authorCalderone, Richard
dc.contributor.authorSun, Nuo
dc.contributor.authorGay-Andrieu, Francoise
dc.contributor.authorGroutas, William C.
dc.contributor.authorWeerawarna, Pathum M.
dc.contributor.authorPrasad, Sridhar
dc.contributor.authorAlex, Deepu
dc.contributor.authorLi, Dongmei
dc.date.accessioned2014-10-06T19:28:32Z
dc.date.available2014-10-06T19:28:32Z
dc.date.issued2014-06
dc.identifier.citationCalderone, Richard; Sun, Nuo; Gay-Andrieu, Francoise; Groutas, William C.; Weerawarna, Pathum M.; Prasad, Sridhar; Alex, Deepu; Li, Dongmei. 2014. Antifungal drug discovery: the process and outcomes. Future Microbiology, June 2014:vol. 9:no. 6:pp 791-805en_US
dc.identifier.issn1746-0913
dc.identifier.otherWOS:000339912100012
dc.identifier.urihttp://dx.doi.org/10.2217/FMB.14.32
dc.identifier.urihttp://hdl.handle.net/10057/10756
dc.descriptionClick on the DOI link to access the article (may not be free).en_US
dc.description.abstractNew data suggest that the global incidence of several types of fungal diseases have traditionally been under- documented. Of these, mortality caused by invasive fungal infections remains disturbingly high, equal to or exceeding deaths caused by drug-resistant tuberculosis and malaria. It is clear that basic research on new antifungal drugs, vaccines and diagnostic tools is needed. In this review, we focus upon antifungal drug discovery including in vitro assays, compound libraries and approaches to target identification. Genome mining has made it possible to identify fungal-specific targets; however, new compounds to these targets are apparently not in the antimicrobial pipeline. We suggest that 'repurposing' compounds (off patent) might be a more immediate starting point. Furthermore, we examine the dogma on antifungal discovery and suggest that a major thrust in technologies such as structural biology, homology modeling and virtual imaging is needed to drive discovery.en_US
dc.language.isoen_USen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofseriesFuture Microbiology;v.9:no.6
dc.subjectAntifungalsen_US
dc.subjectCompound librariesen_US
dc.subjectDiscoveryen_US
dc.subjectDrug targetsen_US
dc.subjectRepurposingen_US
dc.titleAntifungal drug discovery: the process and outcomesen_US
dc.typeArticleen_US
dc.rights.holderFuture Medicine © 2014


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