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dc.contributor.authorHusbands, Aman
dc.contributor.authorBell, Elizabeth M.
dc.contributor.authorShuai, Bin
dc.contributor.authorSmith, Harley M.S.
dc.contributor.authorSpringer, Patricia S.
dc.date.accessioned2014-05-22T18:13:12Z
dc.date.available2014-05-22T18:13:12Z
dc.date.issued2007-09-17
dc.identifier.citationHusbands, Aman, Bell, Elizabeth M., Shuai, Bin, Smith, Harley M.S., and Patricia S. Springer. 2007. LATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteins. -- Nucleic Acids Research, 2007, pp.1-9 doi:10.1093/nar/gkm775en_US
dc.identifier.issn1362-4962
dc.identifier.issn0305-1048
dc.identifier.urihttp://dx.doi.org/doi:10.1093/nar/gkm775
dc.identifier.urihttp://hdl.handle.net/10057/10575
dc.description© 2007 The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractConserved in a variety of evolutionarily divergent plant species, LOB DOMAIN (LBD) genes define a large, plant-specific family of largely unknown function. LBD genes have been implicated in a variety of developmental processes in plants, although to date, relatively few members have been assigned functions. LBD proteins have previously been predicted to be transcription factors, however supporting evidence has only been circumstantial. To address the biochemical function of LBD proteins, we identified a 6-bp consensus motif recognized by a wide cross-section of LBD proteins, and showed that LATERAL ORGAN BOUNDARIES (LOB), the founding member of the family, is a transcriptional activator in yeast. Thus, the LBD genes encode a novel class of DNA-binding transcription factors. Post-translational regulation of transcription factors is often crucial for control of gene expression. In our study, we demonstrate that members of the basic helix–loop–helix (bHLH) family of transcription factors are capable of interacting with LOB. The expression patterns of bHLH048 and LOB overlap at lateral organ boundaries. Interestingly, the interaction of bHLH048 with LOB results in reduced affinity of LOB for the consensus DNA motif. Thus, our studies suggest that bHLH048 post-translationally regulates the function of LOB at lateral organ boundaries.en_US
dc.description.sponsorshipThis work was funded by National Science Foundation grants (IBN-0318822 and IOS-0420202 to P.S.). Funding to pay the Open Access publication charges for this article was provided by NSF grant (IOS-0420202).en_US
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesNucleic Acids Research, 2007;
dc.subjectLATERAL ORGAN BOUNDARIES (LOB)en_US
dc.titleLATERAL ORGAN BOUNDARIES defines a new family of DNA-binding transcription factors and can interact with specific bHLH proteinsen_US
dc.typeArticleen_US


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