Significant progress in stem cell treatment for alzheimer's disease
Petkova, Karina Neupane, Prabriti Schmitt, Sarah Neupane, Nischal Loganathan, Rajprasad Yao, Li
Petkova, Karina
Neupane, Prabriti
Schmitt, Sarah
Neupane, Nischal
Loganathan, Rajprasad
Yao, Li
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2025-07-02
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K. Petkova et Al. (2025). In Haider, K.H. (Ed.). (2025). Handbook of Regenerative Medicine: Stem Cell-based Approach (1st ed.). CRC Press. https://doi.org/10.1201/9781003464594
Abstract
Alzheimer's disease (AD) is a significant health problem and the most common cause of dementia. The crucial pathological change of AD is the deposition of beta-amyloid (ßA) in the extracellular matrix in the central nervous system and the intracellular accumulation of hyperphosphorylated tau protein in neurons. Neuroinflammation and oxidative stress result in neuron death and, therefore, cause a progressive neurodegenerative disorder. The removal of toxic deposits and the replacement of lost neurons have been the target of AD therapy. However, the current drug treatment of AD using cholinesterase inhibitors and N-methyl-D aspartate (NMDA) receptor antagonists has achieved limited clinical outcomes. Stem cell therapy for AD has attracted significant attention because stem cells can potentially replace neuron loss and reduce inflammation in the neural tissue. In this chapter, we will review the advancements in the investigation of stem cells for AD treatment at tissue, cellular, and molecular levels. © 2025 Karina Petkova, Prabriti Neupane, Sarah Schmitt, Nischal Neupane, Rajprasad Loganathan, Li Yao. All rights reserved.
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CRC Press
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Handbook of Regenerative Medicine: Stem Cell-based Approach