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Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
Burns, Dennis H. English, Douglas S.
Burns, Dennis H.
English, Douglas S.
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WO/2017/132561
Adobe PDF, 2.11 MB
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2017-08-03
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Burns, D.H., English, D.S., inventors; Wichita State University, assignees. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. World Intellectual Property Organization WO/2017/132561. 2017, August 3.
Abstract
Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
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WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
International Application No: PCT/US2017/015428 filed January 27, 2017. Patent No: WO/2017/132561 granted August 3, 2017.
International Application No: PCT/US2017/015428 filed January 27, 2017. Patent No: WO/2017/132561 granted August 3, 2017.
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World Intellectual Property Organization
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Status: Publication 2017-08-03