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Cardiac dysfunction in the diabetic rat: Quantitative evaluation using high resolution magnetic resonance imaging
Loganathan, Rajprasad Bilgen, Mehmet Al-Hafez, Baraa Alenezy, Mohammed D. Smirnova, Irina V.
Loganathan, Rajprasad
Bilgen, Mehmet
Al-Hafez, Baraa
Alenezy, Mohammed D.
Smirnova, Irina V.
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Issue Date
2006-04-04
Type
Article
Genre
Keywords
Left ventricle,Cardiac cycle,Diabetic group,Diabetic cardiomyopathy,Diabetic heart
Subjects (LCSH)
Citation
Loganathan, R., Bilgen, M., Al-Hafez, B. et al. Cardiac dysfunction in the diabetic rat: quantitative evaluation using high resolution magnetic resonance imaging. Cardiovasc Diabetol 5, 7 (2006). https://doi.org/10.1186/1475-2840-5-7
Abstract
Background
Diabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy.
Methods
In this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional characteristics of streptozotocin treated diabetic Sprague-Dawley rats (8 weeks disease duration) in comparison with age/sex matched controls.
Results
Our analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. Mean stroke volume and ejection fraction in diabetic rats were decreased (48% and 28%, respectively) compared to controls. Further, dV/dt changes were suggestive of phase sensitive differences in left ventricular kinetics across the cardiac cycle between diabetic and control rats.
Conclusion
Thus, the MRI analyses of diabetic left ventricle suggest impairment of diastolic and systolic hemodynamics in this rat model of diabetic cardiomyopathy. Our studies also show that in vivo MRI could be used in the evaluation of cardiac dysfunction in this rat model of type 1 diabetes.
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The article can be found here: https://rdcu.be/eADrr
Publisher
BioMed Central
Journal
Cardiovascular Diabetology
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Series
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Archival Collection
PubMed ID
ISSN
1475-2840