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Deuterated protease inhibitors
Chang, Kyeong-Ok Kim, Yunjeong Groutas, William C. Perlman, Stanley
Chang, Kyeong-Ok
Kim, Yunjeong
Groutas, William C.
Perlman, Stanley
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WO/2021/252634
Adobe PDF, 2.14 MB
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2021-12-16
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Chang, K., Kim, Y., Groutas, W.C., Perlman, S., inventors; Wichita State University, Kansas State University Research Foundation, University Of Iowa Research Foundation, assignees. Deuterated protease inhibitors. World Intellectual Property Organization WO/2021/252634. 2021, December 16.
Abstract
Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornaviru s -like supercluster, including coronavirus having a formula: (I) or a prodrug or pharmaceutically-acceptable salt thereof, where: each X comprises at least one cyclic moiety directly attached to the oxygen or connected via an alkyl linkage, where at least one of the linkage and/or the X moiety comprises a deuterium substitution; and Z is selected from the group consisting of aldehydes and bisulfite salts, or the ester or carbamate prodrugs thereof.
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WSU inventor: Groutas, William C., Dept. of Chemistry, College of Liberal Arts and Sciences
International Application No: PCT/US2021/036625 filed June 9, 2021. Patent No: WO/2021/252634 granted December 16, 2021.
International Application No: PCT/US2021/036625 filed June 9, 2021. Patent No: WO/2021/252634 granted December 16, 2021.
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World Intellectual Property Organization
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Status: Publication 2021-12-16