Loading...
Designing and analysis of hydrogel-based targeted hormone therapy for post-breast cancer treatments
Mousa, Mennatallah
Mousa, Mennatallah
Citations
Altmetric:
Files
Loading...
t24060s_Mousa.pdf
Adobe PDF, 2.06 MB
Authors
Other Names
Location
Time Period
Advisors
Original Date
Digitization Date
Issue Date
2024-12
Type
Thesis
Genre
Keywords
Subjects (LCSH)
Electronic dissertations
Citation
Abstract
Breast cancer is a major global health concern for women, with existing treatments like chemotherapy and hormone therapy often causing severe side effects and limited effectiveness. To improve treatment, this study develops a novel hydrogel-based drug delivery system for post-breast cancer therapy. The system combines tamoxifen with albumin, gelatin, collagen, and polyvinylpyrrolidone (PVP) to create a controlled-release formulation aimed at enhancing therapeutic outcomes and minimizing side effects. A literature review and meta-analysis of hydrogel-based systems, especially those using chitosan, gelatin, and combinations, evaluated their efficacy, safety, and biocompatibility. The analysis found that tamoxifen-loaded hydrogels significantly improve drug localization at tumor sites, reduce systemic toxicity, and enhance treatment efficacy compared to conventional methods. The hydrogel was synthesized from high-purity gelatin, fish collagen, bovine serum albumin (BSA), and PVP. These components were chosen for their biocompatibility and mechanical properties. Tamoxifen was incorporated for controlled, localized delivery. The synthesis involved dissolving components in distilled water, mixing at 37°C, and drying at 36°C. Characterization through Fourier Transform Infrared (FTIR) spectroscopy and other tests assessed the hydrogel’s chemical structure, swelling behavior, and stability. In vitro studies demonstrated superior drug loading and controlled release. The review and meta-analysis suggest that tamoxifen-loaded hydrogels offer sustained release and improved targeting, reducing side effects. Despite significant variability among studies, the results support the potential of this hydrogel system to enhance breast cancer treatment. Future research should focus on refining the hydrogel, optimizing drug release, and validating its efficacy and safety in clinical trials. This novel system offers a promising advancement in targeted hormone therapy, potentially improving patient outcomes.
Table of Contents
Description
Thesis (M.S.)-- Wichita State University, College of Engineering, Dept. of Biomedical Engineering
Publisher
Wichita State University
Journal
Book Title
Series
Digital Collection
Finding Aid URL
Use and Reproduction
© Copyright 2024 by Mennatallah Mousa All Rights Reserved