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Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives

Dou, Dengfeng
; 
Alex, Deepu
; 
Du, Bingfan
; 
Tiew, Kok-Chuan
; 
Aravapalli, Sridhar
; 
Mandadapu, Sivakoteswara Rao
; 
Calderone, Richard
; 
Groutas, William C.
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Authors
Dou, Dengfeng
Alex, Deepu
Du, Bingfan
Tiew, Kok-Chuan
Aravapalli, Sridhar
Mandadapu, Sivakoteswara Rao
Calderone, Richard
Groutas, William C.
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Wichita State University. Department of Chemistry
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2011-10-01
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Bioorganic & medicinal chemistry. 2011 Oct 1; 19(19): 5782-7.
Abstract
A series of broad-spectrum antifungal agents based on the 1,2-benzisothiazol-3(2H)-one scaffold is reported. Preliminary structure-activity relationship studies have established the importance of the presence of the heterocyclic ring, a methyl group, and a phenyl ring for optimal manifestation of antifungal activity.
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Elsevier
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Bioorganic & medicinal chemistry
Bioorg. Med. Chem.
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http://dx.doi.org/10.1016/j.bmc.2011.08.029
 http://hdl.handle.net/10057/4334
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1464-3391
0968-0896
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