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Protective antigen complexes with increased stability and uses thereof
Bann, James G. Miyagi, Masaru
Bann, James G.
Miyagi, Masaru
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U.S. 20180169208 A1
Adobe PDF, 514.61 KB
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2018-06-21
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Bann, James G.; Miyagi, Masaru, inventors. Wichita State University; Case Western Reserve University, assignees. Protective antigen complexes with increased stability and uses thereof. United States patent US 20180169208 A1. 2018, June 21.
Abstract
Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The stabilized complex comprises protective antigen protein and capillary morphogenesis protein-2, with the capillary morphogenesis protein-2 being bound to the protective antigen protein along a binding interface. The stabilized protective antigen complex has increased thermal and structural stability, along with resistance to premature proteolytic degradation. Methods of using the same to induce an immunogenic response in a subject against B. anthracis infection are also disclosed.
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WSU inventor: James G. Bann, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 15/886112 filed February 1, 2018. Patent No: US 20180169208 A1 granted June 21, 2018.
Application No: 15/886112 filed February 1, 2018. Patent No: US 20180169208 A1 granted June 21, 2018.
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United States Patent and Trademark Office
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Status: Active; Anticipated expiration: 2036-01-04