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Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
Burns, Dennis H. English, Douglas S.
Burns, Dennis H.
English, Douglas S.
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U.S. 20200261415 A1
Adobe PDF, 1.2 MB
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2020-08-20
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Burns, D.H., English, D.S., inventors. Wichita State University, assignee. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. United States patent US 20200261415 A1. 2020, August 20.
Abstract
Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
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WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No: 16/869745 filed May 8, 2020. Patent No: US 20200261415 A1 granted August 20, 2020.
Application No: 16/869745 filed May 8, 2020. Patent No: US 20200261415 A1 granted August 20, 2020.
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United States Patent and Trademark Office
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Status: Abandoned