Combining bioscaffolds and iPSCs in the treatment of neural trauma and Alzheimer’s disease
Brice, Ryan Kehler, Joshua Lee Yao, Li
Brice, Ryan
Kehler, Joshua Lee
Yao, Li
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2021-06-04
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Book chapter
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Keywords
Alzheimer's disease,Biomaterials,Drug delivery,Induced pluripotent stem cells,Microenvironment,Peripheral nerve injury,Regeneration,Scaffolds,Spinal cord injury,Stem cell therapy,Stem cells
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Citation
Brice, R., Kehler, J., &; Yao, L. (2021, June 4). Combining bioscaffolds and iPSCs in the treatment of neural trauma and Alzheimer's disease. Methods in iPSC Technology. Retrieved April 26, 2022, from https://www.sciencedirect.com/science/article/pii/B9780323857666000073
Abstract
The discovery of induced pluripotent stem cells (iPSCs) was a breakthrough in biological research poised to be a potential therapy in the field of regenerative medicine. The modality is a personalized therapy due to utilizing the patients’ own cells in the treatment of disease. Biomaterial scaffolds constructed from natural and synthetic polymers have both shown to increase stem cell viability in vivo via providing a controlled microenvironment which permits successful cell growth and differentiation. The use of biodegradable and biocompatible three-dimensional (3D) bioscaffolds combined with iPSCs is a promising therapeutic strategy for enhancing regenerative potential and restoring spinal cord function after injury. Bioscaffolds also create a 3D model for the investigation of Alzheimer’s disease. In this work, we reviewed the advance of the research with combination of bioscaffolds and iPSCs for the investigation and treatment of neural trauma and Alzheimer’s disease.
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Elsevier