Enantiomer separations by capillary electrophoresis
Scriba, Gerhard K. E. Harnisch, Henrik Zhu, Qingfu
Scriba, Gerhard K. E.
Harnisch, Henrik
Zhu, Qingfu
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2016-09-20
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Article
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Capillary electrophoresis,Enantiomer separation,Chiral separation,Chiral selector,Migration mode
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Scriba, Gerhard K. E.; Harnisch, Henrik; Zhu, Qingfu. 2016. Enantiomer separations by capillary electrophoresis. Capillary Electrophoresis, vol. 1483 of the series Methods in Molecular Biology:pp 277-299
Abstract
Capillary electrophoresis (CE) is a versatile and flexible technique for analytical enantioseparations. This is due to the large variety of chiral selectors as well as the different operation modes including electrokinetic chromatography, micellar electrokinetic chromatography, and microemulsion electrokinetic chromatography. The chiral selector, which is added to the background electrolyte, represents a pseudostationary phase with its own electrophoretic mobility allowing a variety of different separation protocols. The present chapter briefly addresses the basic fundamentals of CE enantioseparations as well as the most frequently applied chiral selectors and separation modes. The practical example illustrates the separation of the enantiomers of a positively charged analyte using native and charged cyclodextrin derivatives as chiral selectors.
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Springer New York
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Capillary Electrophoresis;v.1483
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1064-3745