Complexities of personalized medicine: How genes, drug-drug interactions, dosing schedules, and other factors can combine to produce clinically meaningful differences in a drug's effect
Preskorn, Sheldon H.
Preskorn, Sheldon H.
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2013-09
Type
Review
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Keywords
Cytochrome P450 enzymes,Drug-drug interactions,Genetic polymorphism,hERG,Iloperidone,Personalized medicine,Pharmacodynamics,Pharmacokinetics,QTc interval
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Citation
Preskorn, Sheldon H. MD. Complexities of Personalized Medicine: How Genes, Drug-Drug Interactions, Dosing Schedules, and Other Factors Can Combine to Produce Clinically Meaningful Differences in a Drug’s Effect. Journal of Psychiatric Practice 19(5):p 397-405, September 2013. | DOI: 10.1097/01.pra.0000435038.91049.cb
Abstract
Given increased knowledge from molecular biology and pharmacology, it is apparent that multiple factors can interact to produce clinically meaningful differences in a drug's effect in specific individuals (i.e., personalized medicine). This topic is discussed in this column using iloperidone as an example. The variables discussed include dose, dosing schedule, genes, drug-drug interactions, and other medical factors. How such variables can combine to alter a drug's effect is illustrated with a case example and the results of a thorough QTc study of iloperidone. Copyright © Lippincott Williams & Wilkins.
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Wolters Kluwer Health
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Journal of Psychiatric Practice
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15274160